Encyclopedia entry
In Vivo Toxicity Studies of Metal and Metal Oxide Nanoparticles
General, Applied and Systems Toxicology
John Wiley & Sons, Ltd
10/23/2009
DOI: 10.1002/9780470744307.gat244
Abstract
Manufactured nanomaterials are in more than 1000 consumer products that contain some nanotechnology‐based material on the market today. In the last five years there has been much effort put toward understanding the health effects associated with nanoparticle exposure. Toxicity assessment plays a significant role in this effort since human exposure can occur during production processes, handling, as well as their use and application. Although, though there is a large body of literature on “ultrafine particles” from a pulmonary exposure assessment, one should proceed with caution to expand this information to nanomaterials as we are still just at the beginning stages of their toxicity assessment. In this chapter, we consider the respiratory system as the main route of exposure to nanoparticles and we focus our attention mainly on metal‐based nanomaterials and
in vivo
models used to evaluate them. We also discuss available data for other materials, since similar material properties whether size, shape, or chemical composition could lead to comparable toxicities and this will help in the development of screening strategies for nanomaterials that are very much warranted at this time.
Details
- Title: Subtitle
- In Vivo Toxicity Studies of Metal and Metal Oxide Nanoparticles
- Creators
- Andrea Adamcakova-Dodd - University of Iowa Department of Occupational and Environmental Health Iowa City IA USAPeter S Thorne - University of Iowa Department of Occupational and Environmental Health and Department of Civil and Environmental Engineering Iowa City IA USAVicki H Grassian - University of Iowa Interdisciplinary Graduate Program in Human Toxicology Iowa City IA USA University of Iowa Department of Chemistry and Department of Chemical & Biochemical Engineering Iowa City IA USA
- Contributors
- Bryan Ballantyne (Editor) - Independent Consultant in Occupational and Clinical Toxicology Charleston West Virginia USA 25304Timothy C Marrs (Editor) - Edentox Associates Edenbridge Kent UK TN8 6AQ National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit City Hospital Birmingham UK B18 7QH University of Central Lancashire Lancashire School of Health and Postgraduate Medicine Preston UK PR1 2HETore Syversen (Editor) - Professor of Toxicology, Norwegian University of Science and Technology Department of Neuroscience, Faculty of Medicine Trondheim Norway N‐7489Daniel A Casciano (Editor) - University of Arkansas at Little Rock Little Rock Arkansas USASaura C Sahu (Editor) - US Food and Drug Administration Laurel Maryland USA
- Resource Type
- Encyclopedia entry
- Publication Details
- General, Applied and Systems Toxicology
- DOI
- 10.1002/9780470744307.gat244
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 32
- Language
- English
- Date published
- 10/23/2009
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; Stead Family Department of Pediatrics; Chemistry; Chemical and Biochemical Engineering
- Record Identifier
- 9984001085602771
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