Regulated versus Constitutive Secretion – A Major Form of Intercellular Communication

J. Stöckli; R.C. Piper; D.E. James

doi:10.1016/B978-0-12-394447-4.20037-0

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Regulated versus Constitutive Secretion – A Major Form of Intercellular Communication

J. Stöckli, R.C. Piper and D.E. James

Encyclopedia of Cell Biology, pp.376-383

Elsevier Inc

2016

DOI: 10.1016/B978-0-12-394447-4.20037-0

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Abstract

The secretory pathway carries proteins to the cell surface membrane where they can be released. For many proteins, this transport process happens at a relatively constant rate that is determined by how quickly those proteins are synthesized. The regulated secretory system operates alongside the regular constitutive secretory pathway. It operates by creating a storage compartment within cells. Upon the right stimulus, these storage compartments fuse with the cell surface allowing a burst of contents to be secreted quickly. Regulated secretion is used throughout multicellular organisms to accomplish a wide variety of tasks such as hormonal control and neuronal communication.

Cargo

Dense-core granule

Endocytosis

Exocytosis

Fusion

Golgi

Hormone

Neurotransmission

Secretion

SNARE complex

Storage compartment

Synaptic membrane transport

Transport vesicle

Details

Title: Subtitle: Regulated versus Constitutive Secretion – A Major Form of Intercellular Communication
Creators: J. Stöckli - The University of Sydney, NSW, Australia
R.C. Piper - University of Iowa
D.E. James - The University of Sydney, NSW, Australia
Resource Type: Encyclopedia entry
Publication Details: Encyclopedia of Cell Biology, pp.376-383
DOI: 10.1016/B978-0-12-394447-4.20037-0
Publisher: Elsevier Inc
Language: English
Date published: 2016
Academic Unit: Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
Record Identifier: 9984297600702771

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