Role of Gene Transcription in Long-Term Memory Storage

J Hawk; T Abel

doi:10.1016/B978-0-12-809324-5.00422-3

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Role of Gene Transcription in Long-Term Memory Storage

J Hawk and T Abel

Reference Module in Neuroscience and Biobehavioral Psychology

Elsevier Inc

2017

DOI: 10.1016/B978-0-12-809324-5.00422-3

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Abstract

The formation of long-term memories requires the synthesis of new mRNA. Genetic approaches over the past several decades have identified signaling transduction mechanisms and transcription factors that guide this process and genes that have increased expression after learning. The expression patterns of these genes are elucidating systems- and network-level questions about learning and memory. Recent studies suggest that the epigenetic modifications that regulate transcription are critical for memory storage. Thus, genetic studies have demonstrated that memory formation requires molecular processes that regulate neuronal transcription after learning and suggest that the epigenetic modifications may store information that guides behavior.

Consolidation

Neuron

Amygdala

Transcription

Memory

Plasticity

Epigenetics

Histone modification

Gene expression

Transcription factor

Hippocampus

Details

Title: Subtitle: Role of Gene Transcription in Long-Term Memory Storage
Creators: J Hawk - Yale University, New Haven, CT, United States
T Abel - University of Pennsylvania, Philadelphia, PA, United States
Resource Type: Encyclopedia entry
Publication Details: Reference Module in Neuroscience and Biobehavioral Psychology
DOI: 10.1016/B978-0-12-809324-5.00422-3
Publisher: Elsevier Inc
Language: English
Date published: 2017
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984070414702771

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