Encyclopedia entry
TNF Receptor Superfamily Signaling Pathways in Immune Cells
Encyclopedia of Immunobiology, pp.115-123
Elsevier
01/01/2016
DOI: 10.1016/B978-0-12-374279-7.11016-1
Abstract
Various members of the large and multifunctional tumor necrosis factor receptor superfamily (TNFRSF) of molecules are expressed on all mammalian cell types. These receptors play multiple important regulatory roles in the biology and effector functions of cells of the immune system. The mechanisms and pathways of signal transduction employed by the TNFRSF share the themes of association with adapter proteins, linking them to regulation of downstream kinases and phosphatases, which in turn regulate factors mediating gene expression. The most frequently used family of adapter proteins that associate with members of the TNFRSF is the TNFR-associated factors, which in turn most frequently interact with and regulate members of the mitogen-activated protein kinases. The most studied transcriptional activation pathways downstream of the TNFRSF receptors are those of canonical and noncanonical NF-kappa B factors. There is, however, much individual variation between receptors and the cell types expressing them in which members of each of these signaling protein families are used, and additional adapter proteins, kinases, and transcription factors are also involved. This brief article discusses signaling pathways utilized by TNFRSF receptors expressed by cells of the immune system.
Details
- Title: Subtitle
- TNF Receptor Superfamily Signaling Pathways in Immune Cells
- Creators
- Gail A. Bishop - University of IowaLaura L. Stunz - Univ Iowa, Iowa City, IA 52242 USABruce S. Hostager - Univ Iowa, Iowa City, IA 52242 USA
- Contributors
- MJH Ratcliffe (Editor)A DeFranco (Editor)M Miyasaka (Editor)T Mosmann (Editor)
- Resource Type
- Encyclopedia entry
- Publication Details
- Encyclopedia of Immunobiology, pp.115-123
- DOI
- 10.1016/B978-0-12-374279-7.11016-1
- Publisher
- Elsevier; LONDON
- Number of pages
- 9
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Microbiology and Immunology; President; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984297430802771
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