The INK4a/ARF Locus

D.E. Quelle; J. Nteeba; B.W. Darbro

doi:10.1016/B978-0-12-394447-4.30060-8

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The INK4a/ARF Locus

D.E. Quelle, J. Nteeba and B.W. Darbro

Encyclopedia of Cell Biology, pp.447-457

Elsevier Inc

2016

DOI: 10.1016/B978-0-12-394447-4.30060-8

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Abstract

The protein products of the INK4a/ARF gene locus, p16INK4a and ARF, activate distinct protective checkpoints that inhibit cell proliferation and maintain genomic stability in response to cellular stresses. As such, both factors play a central role in tumor suppression and their inactivation is one of the most frequent events in human cancer. Unique roles for p16INK4a and ARF in other key biological processes, such as aging and development, are emerging.

Aging

Apoptosis

ARF

Cancer

Cell cycle

Checkpoint

Cyclin-dependent kinase (Cdk)

Development

Dual coding

Genomic stability

Mouse knockout

p16INK4a

p21Cip1

p53

RB1

Senescence

Spermatogenesis

Stem cell

Details

Title: Subtitle: The INK4a/ARF Locus
Creators: D.E. Quelle - University of Iowa
J. Nteeba - University of Iowa, Iowa City, IA, USA
B.W. Darbro - University of Iowa
Resource Type: Encyclopedia entry
Publication Details: Encyclopedia of Cell Biology, pp.447-457
DOI: 10.1016/B978-0-12-394447-4.30060-8
Publisher: Elsevier Inc
Language: English
Date published: 2016
Academic Unit: Stead Family Department of Pediatrics; Pathology; Medical Genetics and Genomics; Neuroscience and Pharmacology
Record Identifier: 9984303745102771

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