Poster
Alpha-synuclein seed amplification assay performance in 1,145 cases: results from the PPMI Study
Zenodo
08/12/2022
DOI: 10.5281/zenodo.7004865
Abstract
The purpose of this analysis was to confirm prior findings showing high sensitivity and specificity for alpha-synuclein seed amplification from CSF in Parkinson's disease, and to extend these findings to subgroups and prodromal individuals. We found that a-syn SAA accurate differentiates PD patients from healthy controls and from SWEDDS. Subgroups, particularly LRRRK2 PD, had lower rates of SAA positive results. We also found a high rate of SAA positive results in hyposmic and RBD cases, but not in asymptomatic gene carriers of LRRK2 or GBA. These results have implications for clinical trial planning in manifest PD and prodromal cases.
Details
- Title: Subtitle
- Alpha-synuclein seed amplification assay performance in 1,145 cases: results from the PPMI Study
- Creators
- Andrew SiderowfDavid-Erick LafontantKalpana MerchantTanya SimuniLana M. ChahineBrit MollenhauerTatiana ForoudDouglas GalaskoKathleen L. PostonCaroline M. TannerDaniel WeintraubKarl KieburtzChelsea Caspell-GarciaKenneth MarekChristopher S. CoffeyParkinson’s Progression Markers Initiative
- Resource Type
- Poster
- DOI
- 10.5281/zenodo.7004865
- Publisher
- Zenodo
- Number of pages
- LBA7 Siderowf PPMI SAA Poster 081222a
- Language
- English
- Date published
- 08/12/2022
- Academic Unit
- Biostatistics
- Record Identifier
- 9984530557402771
Metrics
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