Poster
Impact of the Dopamine System on Long-term Cognitive Impairment in Parkinson Disease
Zenodo
09/30/2022
DOI: 10.5281/zenodo.7130837
Abstract
We examined the impact does the dopamine system have on long-term cognitive outcomes in Parkinson disease, and found that lower baseline mean striatum dopamine transporter value, four dopamine-related single-nucleotide polymorphisms, and higher dopaminergic medication exposure all were associated with increased risk for long-term cognitive impairment. Thus, alterations in the dopamine system predict development of clinically-relevant, cognitive impairment in Parkinson disease.
Details
- Title: Subtitle
- Impact of the Dopamine System on Long-term Cognitive Impairment in Parkinson Disease
- Creators
- Daniel WeintraubMarina PicilloHyunkeun Ryan ChoChelsea Caspell-GarciaCornelis BlauwendraatEthan G. BrownLana M ChahineChristopher S CoffeyRoseanne D DobkinTatiana ForoudDoug GalaskoKarl KieburtzKenneth MarekKalpana MerchantBrit MollenhauerKathleen L PostonTanya SimuniAndrew SiderowfAndrew SingletonJohn SeibylCaroline M Tanner
- Resource Type
- Poster
- DOI
- 10.5281/zenodo.7130837
- Publisher
- Zenodo
- Language
- English
- Date published
- 09/30/2022
- Academic Unit
- Biostatistics
- Record Identifier
- 9984530377202771
Metrics
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