Thesis
Acute fracture severity, chronic contact stress, and temporal changes in 3d joint space width following tibial pilon fracture
University of Iowa
Master of Science (MS), University of Iowa
Summer 2022
DOI: 10.25820/etd.006627
Abstract
Post-traumatic osteoarthritis (PTOA) is a debilitating disease that causes pain and loss of function in affected joints. It occurs most predictably after a severe joint injury such as an articular fracture. PTOA is marked by a loss of cartilage thickness over time. The cartilage deterioration is believed to be initiated by pathomechanical factors such as acute fracture severity and chronic elevated contact stress. There are no treatments shown to stop the progression of OA once it begins; physicians can only treat symptoms using treatments such as pain medications, bracing, or walking assistive devices. Based on patient scans, it is difficult to determine which joints will develop PTOA and which will remain healthy. Typically, KL grading of plain radiographs is used to track PTOA development in the ankle. KL grading is subjective and is insensitive to early PTOA-associated changes. Detecting PTOA earlier will lay the groundwork for future clinical trials that can test new treatments. Early detection will allow doctors to inform patients of possible projections of their prognosis with ankle PTOA.
This study improves an objective outcome metric to track OA development using joint space width (JSW) narrowing. 3D JSW is acquired from WBCT scans that are later manipulated to create the new joint space narrowing metric. Joint space narrowing serves in this context as a surrogate for joint deterioration. The study detailed in this thesis focuses on the relationship between pathomechaincal risk factors and the loss of 3D JSW in the first two years after fracture.
Details
- Title: Subtitle
- Acute fracture severity, chronic contact stress, and temporal changes in 3d joint space width following tibial pilon fracture
- Creators
- Hannah Jo Smith
- Contributors
- Donald D Anderson (Advisor)J. Lawrence Marsh (Committee Member)Edward Sander (Committee Member)Suresh L Raghavan (Committee Member)
- Resource Type
- Thesis
- Degree Awarded
- Master of Science (MS), University of Iowa
- Degree in
- Biomedical Engineering
- Date degree season
- Summer 2022
- DOI
- 10.25820/etd.006627
- Publisher
- University of Iowa
- Number of pages
- ix, 84 pages
- Copyright
- Copyright 2022 Hannah Smith
- Language
- English
- Description illustrations
- illustrations (chiefly color), graphs, tables
- Description bibliographic
- Includes bibliographical references (pages 78-84).
- Public Abstract (ETD)
Post-traumatic osteoarthritis (PTOA) is a debilitating disease that causes pain and loss of function in affected joints. It occurs most predictably after a severe joint injury such as an articular fracture. PTOA is marked by a loss of cartilage thickness over time. There is no cure for PTOA; physicians can only treat patients’ symptoms using treatments such as pain medications, bracing, or walking assistive devices.
Based on patient scans, it is difficult to determine which joints will develop PTOA and which will remain healthy. Early detection of PTOA will lay the groundwork for future clinical trials that can test new treatments. Early detection will allow doctors to inform patients of possible projections of their prognosis with ankle PTOA.
This study improves an objective outcome metric to track OA development using joint space width narrowing. 3D JSW is acquired from WBCT scans that are later manipulated to create the new joint space narrowing metric. Joint space narrowing can be assumed to approximate thinning cartilage. This study focuses on the relationship between prediction metrics and the loss of 3D JSW in the first two years after fracture.
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center
- Record Identifier
- 9984285247602771
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