Thesis
Candidate gene analysis of 3D dental phenotypes in patients with malocclusion
University of Iowa
Master of Science (MS), University of Iowa
Spring 2014
DOI: 10.17077/etd.imj3h3h6
Abstract
<p>Objectives: About 2% of the US population suffers from severe malocclusion discrepancies that are beyond the limits of orthodontics alone. This study explores correlations between 3D malocclusion phenotypes and craniofacial development genes. Methods: CBCTs (124) or digital casts (161) of 285 subjects with skeletal Class I (n=60), II (n=143) and III (n=82) malocclusion were digitized with 48 dental landmarks. 3D coordinates were superimposed prior to Principal Component (PC) analyses to identify symmetric (sym) and asymmetric (asym) aspects of shape variation related to malocclusion. PCs explaining 51%-67% of total shape variation were regressed on 200 variants genotyped within 75 genes adjusting for race, gender, age and data source.</p>
<p>Results: Significant correlations (p<0.01) were found for sym variation with BMP3, PITX2, MAFB, SNAl3, FGF8, ABCA4-ARHGAP29, FOXL2 and asym variation PAX7, TBX1, LEFTY1, SATB2, SOX2, TP63 and the 400Kb region containing D1S435.</p>
<p>Conclusion: Results suggest genetic pathways associated with malocclusion.</p>
Details
- Title: Subtitle
- Candidate gene analysis of 3D dental phenotypes in patients with malocclusion
- Creators
- Cole Austin Weaver - University of Iowa
- Contributors
- Lina M. Moreno (Advisor)Thomas E. Southard (Committee Member)Veeratrishul Allareddy (Committee Member)Nathan E. Holton (Committee Member)
- Resource Type
- Thesis
- Degree Awarded
- Master of Science (MS), University of Iowa
- Degree in
- Orthodontics
- Date degree season
- Spring 2014
- DOI
- 10.17077/etd.imj3h3h6
- Publisher
- University of Iowa
- Number of pages
- ix, 142 pages
- Copyright
- Copyright 2014 Cole Austin Weaver
- Language
- English
- Description illustrations
- color illustrations
- Description bibliographic
- Includes bibliographical references (pages 119-142).
- Academic Unit
- Orthodontics; Craniofacial Anomalies Research Center
- Record Identifier
- 9983777217002771
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