<p>In this study we compare the ability of nitrifying activated sludge (NAS) and nitrifying trickling filter (NTF) wastewater treatment to remove the following contaminants: acetaminophen, caffeine, 1,7-dimethylxanthine, cotinine, ibuprofen, sulfamethoxazole, triclosan, and trimethoprim. Removal of acetaminophen, cotinine and caffeine was greater than 99% and removal 1,7-dimethylxanthine, ibuprofen, and triclosan was greater than 90% using NAS and NTF treatment. Sulfamethoxazole and trimethoprim were inadequately removed in both NAS and NTF treatments. The horizontal, subsurface flow treatment wetland showed removals of 45-89% for sulfamethoxazole and greater than 96% for trimethoprim. There was no statistical difference (P>0.05) between aeration, temperature and vegetation in the treatment wetland for the removal of sulfamethoxazole and trimethoprim.</p>