Halodefluorination of unactivated trifluoromethyl compound and MOFs doped with boronic acid for glucose sensing

Fluorine is often added to chemicals to make them work better in medicines, farming products, and new materials. When fluorine sticks to carbon (called a C–F bond), it makes the chemical strong and long-lasting. But that strength also makes it hard to change or break the bond when scientists want to. This causes problems when we try to reuse or safely get rid of these chemicals.

Chapter 1 looks at how these fluorine-containing chemicals are used and how scientists are trying to work with them. The chapter talks about different tools and tricks, like using metals, electricity, or special helper chemicals (called Lewis acids), to break or change the C–F bond. A big focus is on using elements like phosphorus, silicon, aluminum, and boron to do this job in a more selective and controlled way.

Chapter 2 talks about new research to change a common fluorine group (called CF₃). The idea was to swap some of the fluorine atoms with other atoms like chlorine or bromine using iron and boron-based chemicals. The study tested different amounts and timings to see what worked best. It even discovered a new product that hadn’t been made before. This chapter also explains how the reaction might happen, step by step. The products of this chemistry can be used to help make medicines or materials.

Chapter 3 moves in a different direction. It looks at how to make new materials that can help detect sugars like glucose (the sugar in your blood). The study used tiny materials made of metals and other parts, then added something called boronic acids, which are good at sticking to sugars. Two different materials were tested to see how well they could catch glucose. Then, the study tried glowing dyes to “light up” when glucose was present. Only one dye worked well. While this work is ongoing, the final version is designed to let scientists “see” when glucose is around, and it be used again and again.

In short, this thesis explores two main ideas: how to safely change chemicals that have strong fluorine bonds, and how to build smart materials that can detect sugar in a simple, reusable way. These findings could help us make better medicines and better tools for health care in the future.