This research focused on comparing the durability of two different tooth preparation designs, known as posterior indirect adhesive restorations (PIAR), made with modern technology that enables the design and fabrication of dental restorations using a computerized system known as Computer-aided design and Computer-aided manufacturing (CAD/CAM) to ensure high precision and efficiency. We tested how well two different PIAR designs, made from advanced dental materials, could withstand pressure compared to unaffected, healthy teeth. The study involved testing in the laboratory 75 human molars under conditions that mimic the mechanical and thermal stresses teeth may undergo over about three years. The teeth were divided into groups: one with sound or intact teeth and the others featuring various combinations of restorative designs and materials. We subjected these teeth to intense compressive pressure to determine at what point they would break, using a process that simulates the kind of force a tooth would experience in daily use. Our finding showed that the type of material or the specific design of the PIAR did not significantly impact the tooth’s ability to resist breaking when compared to an unaltered tooth. We also found that the pattern of how these materials broke under pressure varied, with some types of fractures able to withstand more force than others. The conclusion from our study is reassuring for dental practice: when meticulous care is taken in applying these advanced repair materials and methods, the restored teeth can be just as robust as their healthy counterparts, regardless the effectiveness of modern dental restoration techniques, offering promising outcomes for patients receiving such treatments.