Thesis
Measuring 3D joint space width from weight bearing CT to monitor progression of knee osteoarthritis
University of Iowa
Master of Science (MS), University of Iowa
Spring 2020
DOI: 10.17077/etd.005422
Abstract
Monitoring the progression of knee osteoarthritis (OA) in a clinical setting has proven to be challenging with current methods of detecting changes in the joint demonstrating poor sensitivity to biomarkers associated with joint degeneration. Other methods of detecting disease progression like MRI, are much more expensive and not readily available in a clinical setting. The development of low dose weight-bearing CT (WBCT) scans holds potential to overcome some of these problems through 3D joint space width (JSW) measurement.
The goal of this study was to assess the sensitivity of 3D JSW measurements using WBCT to detect changes in the joint associated with the development of OA. The existing JSW measurement process was improved upon and compared to current clinical methods of monitoring OA in the knee.
The 3D JSW measurement method compared favorably with present clinical metrics. The responsiveness to changes in the knee joint was much better than current methods of analysis used in a clinical setting. It also improved upon subjective methods currently used by clinicians to classify the state of OA.
3D JSW is a metric that shows promise in analyzing knee joints for the progression of OA. Speeding up 3D JSW measurement could greatly influence the ability to measure the effectiveness of treatments used to prevent the progression of OA.
Details
- Title: Subtitle
- Measuring 3D joint space width from weight bearing CT to monitor progression of knee osteoarthritis
- Creators
- Michael Shinriki Ho
- Contributors
- Donald D Anderson (Advisor)Neil A Segal (Committee Member)Nicole M Grosland (Committee Member)Colleen L Bringman (Committee Member)
- Resource Type
- Thesis
- Degree Awarded
- Master of Science (MS), University of Iowa
- Degree in
- Biomedical Engineering
- Date degree season
- Spring 2020
- DOI
- 10.17077/etd.005422
- Publisher
- University of Iowa
- Number of pages
- xii, 96 pages
- Copyright
- Copyright 2020 Michael Shinriki Ho
- Language
- English
- Description illustrations
- color illustrations
- Description bibliographic
- Includes bibliographical references (pages 94-96).
- Public Abstract (ETD)
Monitoring the progression of knee osteoarthritis (OA) in a clinical setting has proven to be challenging with current methods of detecting changes in the joint demonstrating poor sensitivity to biomarkers associated with joint degeneration. Other methods of detecting disease progression like MRI, are much more expensive and not readily available in a clinical setting. The development of low dose weight-bearing CT (WBCT) scans holds potential to overcome some of these problems through 3D joint space width (JSW) measurement.
3D models of the knee joint are created to measure the distance between the bones and monitor joint narrowing which is often associated with the progression of OA. This study improves upon current methods of measuring the JSW and showed better responsiveness to narrowing of the JSW in the knee. Therefore, 3D JSW measurement shows promise in being able to detect early progression of OA in a clinical setting.
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9983949491502771
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