Files and links (1)
Free to read and download, Open Access
Thesis
Rotating-shield brachytherapy (RSBT) for cervical cancer
University of Iowa
Master of Science (MS), University of Iowa
Summer 2012
DOI: 10.17077/etd.j28gul4x
Abstract
<p>Purpose: To assess rotating shield brachytherapy (RSBT) delivered with the electronic brachytherapy (eBT) source comparing to intracavitary (IC) and intracavitary plus supplemental interstitial brachytherapy (IC+IS BT) delivered with a conventional 192Ir radioactive source.</p>
<p>Method and Materials: IC, IC+IS and RSBT treamtent plan were simulated for 5 patients with bulky (>40 cc) cervical cancer. One BT plan for each patient (fraction 1) guided by magnetic resonance imaging (MRI) was used in our treatment planning system (TPS). A bio- and MRI-compatible polycarbonate (Makrolon Rx3158) intrauterine applicator was simulated for IC and RSBT, and the Vienna applicator was simulated for IC+IS BT. 192Ir was used as the radiation source of IC and IC+IS BT, and the Xoft AxxentTM eBT source was used for RSBT. A 0.5 mm thick tungsten shield was used for RSBT with different azimuthal and zenith angles, which reduced radiation transmission through the shield to less than 0.1%. The total dose delivered was calculated as the external beam radiation therapy (EBRT) dose plus the BT dose delivered over five treatment fractions.</p>
<p>Results: RSBT and IC+IS BT had higher dose conformity in terms of the minimum dose to the hottest 90% (D90) of the high-risk clinical target volume (HR-CTV) than IC BT for all the patients. The advantage of RSBT over IC+IS BT was dependent on the shield emission angle, tumor shape and tandem applicator location. The delivery time of RSBT was increased as finer emission angle were selected.</p>
<p>Conclusions: RSBT is a less-invasive potential alternative to conventional IC and IC+IS BT for treating bulky cervical cancer. RSBT delivery times are clinically acceptable if proper emission angle is selected based on the tumor shape and tandem applicator location.</p>
Details
- Title: Subtitle
- Rotating-shield brachytherapy (RSBT) for cervical cancer
- Creators
- Wenjun Yang - University of Iowa
- Contributors
- Ryan T. Flynn (Advisor)Joseph M. Reinhardt (Committee Member)John E. Bayouth (Committee Member)Yusung Kim (Committee Member)
- Resource Type
- Thesis
- Degree Awarded
- Master of Science (MS), University of Iowa
- Degree in
- Biomedical Engineering
- Date degree season
- Summer 2012
- Publisher
- University of Iowa
- DOI
- 10.17077/etd.j28gul4x
- Number of pages
- vii, 26 pages
- Copyright
- Copyright 2012 Wenjun Yang
- Language
- English
- Description illustrations
- col. illustrations, charts
- Description bibliographic
- Includes bibliographical references (pages 25-26).
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9983777366802771
Metrics
1385 File views/ downloads
248 Record Views