The NGF enigma: exploring NGF signaling in axon survival

Nerve cells have long tail-like projections called axons, which transmit electrical signals throughout the body. Axon breakdown or damage can be induced by inflammation, physical damage, or other stressors. When axons experience these stressors, their signal transmissions are disrupted, resulting in neuropathic pain, disease, and brain disorders. Diseases like Alzheimer’s or Parkinson’s are some of the most common forms of dementia and are painful and debilitating for many individuals worldwide. While the specific protein, Nerve Growth Factor, supports development and survival of nerve cells, its role in mature nerve cells is yet to be discovered. This series of experiments explores nerve cell survival and maintenance from the reintroduction of NGF after experiencing a deprivation period.