β1,2-Xylosyltransferase Cxt1p Is Solely Responsible for Xylose Incorporation into Cryptococcus neoformans Glycosphingolipids

Sherry A Castle; Elizabeth A Owuor; Stephanie H Thompson; Michelle R Garnsey; J. Stacey Klutts; Tamara L Doering; Steven B Levery

doi:10.1128/EC.00458-07

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β1,2-Xylosyltransferase Cxt1p Is Solely Responsible for Xylose Incorporation into Cryptococcus neoformans Glycosphingolipids

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β1,2-Xylosyltransferase Cxt1p Is Solely Responsible for Xylose Incorporation into Cryptococcus neoformans Glycosphingolipids

Sherry A Castle, Elizabeth A Owuor, Stephanie H Thompson, Michelle R Garnsey, J. Stacey Klutts, Tamara L Doering and Steven B Levery

Eukaryotic cell, Vol.7(9), pp.1611-1615

09/2008

DOI: 10.1128/EC.00458-07

PMCID: PMC2547070

PMID: 18676952

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Abstract

The Manα1,3(Xylβ1,2)Manα structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

Details

Title: Subtitle: β1,2-Xylosyltransferase Cxt1p Is Solely Responsible for Xylose Incorporation into Cryptococcus neoformans Glycosphingolipids
Creators: Sherry A Castle - Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598
Elizabeth A Owuor - Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598
Stephanie H Thompson - Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598
Michelle R Garnsey - Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598
J. Stacey Klutts - Departments of Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110
Tamara L Doering - Departments of Molecular Microbiology
Steven B Levery - Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598
Resource Type: Journal article
Publication Details: Eukaryotic cell, Vol.7(9), pp.1611-1615
DOI: 10.1128/EC.00458-07
PMID: 18676952
PMCID: PMC2547070
NLM abbreviation: Eukaryot Cell
ISSN: 1535-9778
eISSN: 1535-9786
Publisher: American Society for Microbiology
Language: English
Date published: 09/2008
Academic Unit: Pathology
Record Identifier: 9984047724102771

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