Journal article
α 2-Adrenergic receptor gene polymorphism and hypertension in blacks
American journal of hypertension, Vol.8(4), pp.390-394
1995
DOI: 10.1016/0895-7061(95)00024-J
PMID: 7619352
Abstract
α
2-Adrenergic receptors are found on presynaptic neurons of the central and peripheral nervous systems, on blood vessels, on platelets, on adipocytes, and in the kidney and pancreas. Activation of these ubiquitous adrenoreceptors results in decreased neuronal norepinephrine release, vasodilation, a fall in blood pressure, platelet aggregation, increased sodium excretion, and decreased insulin release. We hypothesized that defects in α
2-adrenergic receptors, or postreceptor defects, could explain the increased prevalence of hypertension in blacks. To test our hypothesis, we first determined whether or not a polymorphism of the (α
2-adrenergic receptor gene was associated with pathologic elevations in blood pressure in American blacks. Dra-I identified a restriction fragment-length polymorphism (RFLP) of 6.3 and 6.7 kb of the α
2-adrenergic receptor gene on chromosome 10 in humans. Of 227 patients studied, 13/107 hypertensive subjects were homozygous for the 6.3-kb allele, whereas only 3/120 normotensive volunteers were homozygotes (
P = .008). When analyzed by race, 13/82 black hypertensive subjects were homozygous for the 6.3-kb allele, whereas only 2/59 normotensive blacks were homozygous for the 6.3-kb alleles (
P = .02). However, only 1/61 white normotensiye and 0/25 white hypertensive subjects were homozygous for the 6.3-kb allele (
P = 1.00). Ethnic variation among blacks may explain our findings. Alternatively, a genetic polymorphism in, or near, the α
2-adrenergic receptor on chromosome 10 can contribute to the development of hypertension in blacks.
Details
- Title: Subtitle
- α 2-Adrenergic receptor gene polymorphism and hypertension in blacks
- Creators
- Warren LocketteSanjay GhoshStephen FarrowSteven MacKenzieScott BakerPaul MilesAnthony SchorkLinda Cadaret
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.8(4), pp.390-394
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0895-7061(95)00024-J
- PMID
- 7619352
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 1995
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094655202771
Metrics
14 Record Views