Journal article
α-Dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy
FEBS letters, Vol.350(2), pp.173-176
1994
DOI: 10.1016/0014-5793(94)00748-9
PMID: 8070559
Abstract
The dystrophin—glycoprotein complex was examined in dystrophin-deficient dogs with golden retriever muscular dystrophy (GRMD) using immunoblot and immunofluorescence analysis. The dystrophin-associated proteins were substantially reduced in muscle from dogs with GRMD. Interestingly, regression analysis revealed a strong correlation between the amount of α-dystroglycan and serum creatine kinase levels and the contraction tension measured for a given peroneus longus muscle.
Details
- Title: Subtitle
- α-Dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy
- Creators
- James M Ervasti - Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USAKevin P Campbell - Howard Hughes Medical Institute and Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, USASteven L Roberds - Howard Hughes Medical Institute and Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, USARichard D Anderson - Howard Hughes Medical Institute and Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, USANicholas J.H Sharp - Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USAJoe N Kornegay - Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.350(2), pp.173-176
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-5793(94)00748-9
- PMID
- 8070559
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Language
- English
- Date published
- 1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068264602771
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