Journal article
α-Tocopherol Supplementation for Men with Existing Coronary Artery Disease: A Feasibility Study
Preventive medicine, Vol.29(2), pp.112-118
08/1999
DOI: 10.1006/pmed.1999.0509
PMID: 10446037
Abstract
Background. Recent studies have suggested that α-tocopherol supplementation can help reduce the incidence of coronary disease. Our objectives were to determine the feasibility of providing α-tocopherol supplements to male veterans with existing coronary artery disease and determine its effects on α-tocopherol levels and the susceptibility of low-density lipoprotein (LDL) to oxidation.
Methods. Fifty-seven percent of 138 coronary disease patients were willing to participate in a placebo-controlled trial −25% were already taking antioxidants. Thirty-nine men were randomly assigned to either 400 mg/day of α-tocopherol (n = 27) or placebo (n = 12). α-Tocopherol levels and LDL oxidation (measured by formation of thiobarbituric acid-reactive substance) were measured at baseline and at 6 months.
Results. Thirty-three subjects (22 α-tocopherol, 11 placebo) completed the study; 3 subjects withdrew after suffering coronary disease events. Supplement compliance exceeded 90% and α-tocopherol was well tolerated. The α-tocopherol group had a significantly greater mean increase in lipid-adjusted α-tocopherol levels (73% vs. −4.6%, P < 0.0001), but oxidized LDL did not change significantly.
Conclusions. A secondary prevention trial among veterans would be feasible because the rates of enrollment, completion, compliance, and clinical events were high. α-Tocopherol supplements did not decrease the susceptibility of LDL to oxidation, suggesting that higher dosages or longer duration of supplementation may be required for secondary prevention.
Details
- Title: Subtitle
- α-Tocopherol Supplementation for Men with Existing Coronary Artery Disease: A Feasibility Study
- Creators
- Richard M Hoffman - Department of Medicine, Albuquerque Veterans Affairs Medical Center, University of New Mexico, Albuquerque, New Mexico, 87131Harinder S Garewal - Department of Medicine, Tucson Veterans Affairs Medical Center, Tucson, Arizona, 85723
- Resource Type
- Journal article
- Publication Details
- Preventive medicine, Vol.29(2), pp.112-118
- DOI
- 10.1006/pmed.1999.0509
- PMID
- 10446037
- NLM abbreviation
- Prev Med
- ISSN
- 0091-7435
- eISSN
- 1096-0260
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 08/1999
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094508002771
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