Journal article
α2-Adrenergic modulation of synaptic excitability in the rat nucleus tractus solitarius
Brain research, Vol.480(1), pp.190-197
1989
DOI: 10.1016/0006-8993(89)91582-5
Abstract
These studies examined the effects of the α-adrenergic agonist clonidine on spontaneous and synaptically evoked activity in the solitary tract nucleus in superfused rat brain slices. In one group of neurons which showed no spontaneous spike activity (
n = 27), clonidine superfusion induced a dose-dependent increase of postsynaptic responsiveness to input from the ipsilateral solitary tract. In another group of neurons which were spontaneously active but unresponsive to tract input (
n = 20), clonidine induced a dose-dependent depression of spontaneous discharge. A third group of neurons which were both spontaneously active and responsive to tract input (
n = 11) showed primarily a depression of both activities. The neuronal responses to clonidine in all 3 groups were selectively blocked by the
α
2-adrenoceptor antagonist yohimbine but not by the
α
1-antagonist prazosin. These results provide insight into the possible actions of endogenous adrenergic systems in the synaptic processing of afferent sensory information within the solitary tract nucleus.
Details
- Title: Subtitle
- α2-Adrenergic modulation of synaptic excitability in the rat nucleus tractus solitarius
- Creators
- Peter D FeldmanRobert B Felder
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.480(1), pp.190-197
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(89)91582-5
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1989
- Academic Unit
- Internal Medicine; Cardiovascular Medicine; Iowa Neuroscience Institute
- Record Identifier
- 9984070339802771
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