Journal article
α2-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats
American journal of physiology. Heart and circulatory physiology, Vol.282(6), pp.H2336-H2345
06/01/2002
DOI: 10.1152/ajpheart.00167.2001
Abstract
We examined the effect of α2-adrenoreceptor blockade in the nucleus of the solitary tract (NTS) on baroreflex responses elicited by electrical stimulation of the left aortic depressor nerve (ADN) in urethane-anesthetized spontaneously hypertensive rats (SHR, n = 11) and normotensive Wistar-Kyoto rats (WKY, n = 11). ADN stimulation produced a frequency-dependent decrease in mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and heart rate (HR). In SHR, unilateral microinjection of idazoxan into the NTS markedly reduced baroreflex control of MAP, RSNA, and HR and had a disproportionately greater influence on baroreflex control of MAP than of RSNA. In WKY, idazoxan microinjections did not significantly alter baroreflex function relative to control vehicle injections. These results suggest that baroreflex regulation of arterial pressure in SHR is highly dependent on NTS adrenergic mechanisms. The reflex regulation of sympathetic outflow to the kidney is less influenced by the altered α2-adrenoreceptor mechanisms in SHR.
Details
- Title: Subtitle
- α2-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats
- Creators
- Linda F Hayward - Cardiovascular Center and Department of Internal Medicine, University of Iowa and Research Service of the Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610Alecia P Riley - Cardiovascular Center and Department of Internal Medicine, University of Iowa and Research Service of the Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610Robert B Felder - Cardiovascular Center and Department of Internal Medicine, University of Iowa and Research Service of the Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.282(6), pp.H2336-H2345
- DOI
- 10.1152/ajpheart.00167.2001
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 06/01/2002
- Academic Unit
- Internal Medicine; Cardiovascular Medicine; Iowa Neuroscience Institute
- Record Identifier
- 9984070532602771
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