Journal article
γδ T cell response induced by vaginal Herpes simplex 2 infection
Immunology letters, Vol.70(2), pp.89-93
1999
DOI: 10.1016/S0165-2478(99)00132-7
Abstract
The purpose of the present studies was to determine whether acute vaginal infection with Herpes virus 2 altered the vaginal population of γδ T cells, and whether γδ T cells influenced the vaginal clearance of HSV-2. BALB/c mice were infected intravaginally with the progressively lethal wild type 333 strain, or the non-lethal thymidine kinase deficient (ΔTK
−-HSV-2) mutant strain of HSV-2 virus. Changes in vaginal T cell composition were examined by FACS analysis 4 days after infection. Clearance of vaginal ΔTK
−-HSV-2 infection was compared between mice with normal γδ T cell populations (BALB/c) and transgenic mice in which all the γδ T cells express a receptor that is specific for the b allotype of MHC class Ib T10 antigen (G8/BALB/c). In HSV-2 infected BALB/c mice, but not G8/BALB/c, a subset of γδ T cells that express a Vγ2 TCR accumulated in the vaginal mucosa by the fourth day after infection. Unexpectedly, we found that γδ TCR transgenic mice exhibited a more rapid clearance of the virus than control mice (
P<0.05). These findings argue against the hypothesis that the normal populations of vaginal intraepithelial γδ T cells play a direct role in the elimination of virally infected epithelial cells.
Details
- Title: Subtitle
- γδ T cell response induced by vaginal Herpes simplex 2 infection
- Creators
- Eva Rakasz - Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USAAllan Mueller - Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USAStanley Perlman - Department of Microbiology and Pediatrics, College of Medicine, University of Iowa, Iowa City, IA 52242, USARichard G Lynch - Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Immunology letters, Vol.70(2), pp.89-93
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0165-2478(99)00132-7
- ISSN
- 0165-2478
- eISSN
- 1879-0542
- Language
- English
- Date published
- 1999
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Microbiology and Immunology; Infectious Disease (Pediatrics)
- Record Identifier
- 9984070879902771
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