Journal article
[15O]water pharmacokinetics: influence of age and gender in normal subjects
Molecular imaging and biology, Vol.4(2), pp.129-137
03/2002
DOI: 10.1016/S1095-0397(01)00064-4
PMID: 14537135
Abstract
To compile a normal database for the characterization of global [15O]water pharmacokinetic behavior.
The influences of age, gender, and body habitus on the pharmacokinetics of [15O]water were investigated in a series of normal subjects, N = 100 (50 males, 50 females, age = 19-79) who were participants in cognitive activation studies. Arterial blood was analyzed by autosampler and parametric images were constructed using a 40-second summed image and the autoradiographic model.
Males and females were comparable with respect to age, number of injections administered, and dose (mCi) administered per injection but differed significantly with respect to height, weight, and normalized dose (mCi/kg). There were significant gender-based differences in the bolus arrival time, global cerebral blood flow (gCBF), area-under-the-curve (AUC), summed image concentration, and dose-normalized concentration but not dose-normalized AUC. Bolus arrival time, gCBF and dose-normalized AUC were significantly influenced by age.
Age and gender are significant determinants of [15O]water pharmacokinetic behavior.
Details
- Title: Subtitle
- [15O]water pharmacokinetics: influence of age and gender in normal subjects
- Creators
- Laura L B Ponto - Positron Emission Tomography Imaging Center, University of Iowa, Iowa City, IA 52242, USA. laura-ponto@uiowa.eduG Leonard WatkinsRichard D HichwaJohn C RichmondJo ClarkChristine A WardDean A Clermont
- Resource Type
- Journal article
- Publication Details
- Molecular imaging and biology, Vol.4(2), pp.129-137
- Publisher
- United States
- DOI
- 10.1016/S1095-0397(01)00064-4
- PMID
- 14537135
- ISSN
- 1536-1632
- eISSN
- 1860-2002
- Language
- English
- Date published
- 03/2002
- Academic Unit
- Radiology; Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984051980902771
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