Journal article
18F-labeled lower fluoroalkanes; Reactor-produced gaseous physiological tracers
The International journal of applied radiation and isotopes, Vol.32(4), pp.211-214
1981
DOI: 10.1016/0020-708X(81)90051-X
PMID: 7239701
Abstract
Rapid high-yield syntheses of the four gaseous monofluoroalkanes, CH
3F, C
2H
5F,
n-C
3H
7F and
i-C
3H
7F, labeled with
18F are described. The method involves silver (I) oxide catalyzed nucleophilic substitution of
18F
− for iodide in the respective iodoalkanes, using acetonitrile as solvent at 120°C. The
18F
− was made in a nuclear reactor by irradiation of Li
2CO
3, which was subsequently decomposed with H
+ form ion exchange resin. The resulting aqueous
18F
− was rotary-evaporated to dryness after addition of tetraethylammonium hydroxide.
Ostwald solubility coefficients of the gases were determined radiometrically at 37°C in water, 0.9% saline, plasma, blood and paraffin oil. The aqueous solubilities are all near unity, while the values for oil rise from 1 to 12 in the series CH
3F<C
2H
5F<
i-C
3H
7F<
n-C
3H
7F. Whole- body washout kinetics following equilibration with the
18F gases showed that fluoromethane and fluoroethane, at least, are not metabolized in the rat. The possible utility of
18F-fluoromethane and other
18F gases and vapors in studies of lung-function and blood-flow is discussed.
Details
- Title: Subtitle
- 18F-labeled lower fluoroalkanes; Reactor-produced gaseous physiological tracers
- Creators
- S.J GatleyR.D HichwaW.J ShaughnessyR.J Nickles
- Resource Type
- Journal article
- Publication Details
- The International journal of applied radiation and isotopes, Vol.32(4), pp.211-214
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0020-708X(81)90051-X
- PMID
- 7239701
- ISSN
- 0020-708X
- Language
- English
- Date published
- 1981
- Academic Unit
- Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984213292602771
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