[18F]Fluoro-β-fluoromethylene-m-tyrosine analogs, potential PET agents for presynaptic dopamine terminals : synthesis and spectroscopic characterization

D MURALI; O. T DEJESUS; J. J SUNDERLAND; R. J NICKLES

doi:10.1016/0883-2889(92)90215-Z

Back

Journal article

[18F]Fluoro-β-fluoromethylene-m-tyrosine analogs, potential PET agents for presynaptic dopamine terminals : synthesis and spectroscopic characterization

D MURALI, O. T DEJESUS, J. J SUNDERLAND and R. J NICKLES

International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, Vol.43(8), pp.969-977

1992

DOI: 10.1016/0883-2889(92)90215-Z

PMID: 1330983

View Online

Abstract

FMMT was prepared by the direct reaction of FMMT with [18F]acetylhypofluorite (AcOF) resulting into three product isomers. Extensive 1H, 13C and 19F-NMR spectroscopic analysis identify these products to be 2-fluoro, 6-fluoro-FMMT and 2,6-difluoro-FMMT. The HPLC isolated radiochemical EOB yields of these products were 22, 25 and 14%, respectively, based on starting [18F]AcOF. The specific activity at the end of a synthesis time of an hour was ca 200 mCi/mmol. With the possible advantage of “metabolic trapping” in dopamine nerve terminals via covalent binding to MAO and reduced metabolite formation, [18F]F-FMMT may potentially be the optimal PET tracer for CNS dopamine nerve terminals.

Analytical Chemistry

Chemistry

Chromatographic methods and physical methods associated with chromatography

Exact sciences and technology

Details

Title: Subtitle: [18F]Fluoro-β-fluoromethylene-m-tyrosine analogs, potential PET agents for presynaptic dopamine terminals : synthesis and spectroscopic characterization
Creators: D MURALI - Univ. Wisconsin, dep. medical physics, Madison WI 53706, United States
O. T DEJESUS - Univ. Wisconsin, dep. medical physics, Madison WI 53706, United States
J. J SUNDERLAND - Univ. Wisconsin, dep. medical physics, Madison WI 53706, United States
R. J NICKLES - Univ. Wisconsin, dep. medical physics, Madison WI 53706, United States
Resource Type: Journal article
Publication Details: International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, Vol.43(8), pp.969-977
Publisher: Pergamon; Oxford
DOI: 10.1016/0883-2889(92)90215-Z
PMID: 1330983
ISSN: 0883-2889
Language: English
Date published: 1992
Academic Unit: Radiology; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984046827902771

Metrics

10 Record Views