[18F]fluoroestradiol radiation dosimetry in human PET studies

David A MANKOFF; Lanell M PETERSON; Timothy J TEWSON; Jeanne M LINK; Julie R GRALOW; Michael M GRAHAM; Kenneth A KROHN

[18F]fluoroestradiol radiation dosimetry in human PET studies

Journal article

Peer reviewed

[18F]fluoroestradiol radiation dosimetry in human PET studies

David A MANKOFF, Lanell M PETERSON, Timothy J TEWSON, Jeanne M LINK, Julie R GRALOW, Michael M GRAHAM and Kenneth A KROHN

The Journal of nuclear medicine (1978), Vol.42(4), pp.679-684

2001

PMID: 11337559

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Abstract

[18F]16alpha-fluoroestradiol (FES) is a PET imaging agent useful for the study of estrogen receptors in breast cancer. We estimated the radiation dosimetry for this tracer using data obtained in patient studies. Methods: Time-dependent tissue concentrations of radioactivity were determined from blood samples and PET images in 49 patients (52 studies) after intravenous injection of FES. Radiation absorbed doses were calculated using the procedures of the MIRD committee, taking into account the variation in dose based on the distribution of activities observed in the individual patients. Effective dose equivalent was calculated using International Commission on Radiological Protection Publication 60 weights for the standard woman. Results: The effective dose equivalent was 0.022 mSv/MBq (80 mrem/mCi). The organ that received the highest dose was the liver (0.13 mGy/MBq [470 mrad/mCi]), followed by the gallbladder (0.10 mGy/MBq [380 mrad/mCi]) and the urinary bladder (0.05 mGy/MBq [190 mrad/mCi]). Conclusion: The organ doses are comparable to those associated with other commonly performed nuclear medicine tests. FES is a useful estrogen receptor-imaging agent, and the potential radiation risks associated with this study are well within accepted limits.

Tumors

Gynecology. Andrology. Obstetrics

Mammary gland diseases

Investigative techniques, diagnostic techniques (general aspects)

Endocrine glands. Genital system. Mammary gland

Biological and medical sciences

Radionuclide investigations

Medical sciences

Details

Title: Subtitle: [18F]fluoroestradiol radiation dosimetry in human PET studies
Creators: David A MANKOFF - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Lanell M PETERSON - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Timothy J TEWSON - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Jeanne M LINK - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Julie R GRALOW - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Michael M GRAHAM - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Kenneth A KROHN - Departments of Radiology and Medical Oncology, University of Washington School of Medicine, Seattle, Washington, United States
Resource Type: Journal article
Publication Details: The Journal of nuclear medicine (1978), Vol.42(4), pp.679-684
Publisher: Society of Nuclear Medicine; Reston, VA
PMID: 11337559
ISSN: 0161-5505
eISSN: 1535-5667
Language: English
Date published: 2001
Academic Unit: Radiology; Radiation Oncology
Record Identifier: 9984047720802771

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