Journal article
1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs
Journal of applied physiology (1985), Vol.127(1), pp.122-133
07/01/2019
DOI: 10.1152/japplphysiol.00016.2019
PMCID: PMC6692748
PMID: 31095459
Abstract
This study aimed to introduce a one-dimensional (1D) computational fluid dynamics (CFD) model for airway resistance and lung compliance to examine the relationship between airway resistance, pressure, and regional flow distribution. We employed five healthy and five asthmatic subjects who had dynamic computed tomography (CT) scans (4D CT) along with two static scans at total lung capacity and functional residual capacity. Fractional air-volume change (
Δ
V
air
f
) from 4D CT was used for a validation of the 1D CFD model. We extracted the diameter ratio from existing data sets of 61 healthy subjects for computing mean and standard deviation (SD) of airway constriction/dilation in CT-resolved airways. The lobar mean (SD) of airway constriction/dilation was used to determine diameters of CT-unresolved airways. A 1D isothermal energy balance equation was solved, and pressure boundary conditions were imposed at the acinar region (
model A
) or at the pleural region (
model B
). A static compliance model was only applied for
model B
to link acinar and pleural regions. The values of 1D CFD-derived
Δ
V
air
f
for
model B
demonstrated better correlation with 4D CT-derived
Δ
V
air
f
than
model A
. In both inspiration and expiration, asthmatic subjects with airway constriction show much greater pressure drop than healthy subjects without airway constriction. This increased transpulmonary pressures in the asthmatic subjects, leading to an increased workload (hysteresis). The 1D CFD model was found to be useful in investigating flow structure, lung hysteresis, and pressure distribution for healthy and asthmatic subjects. The derived flow distribution could be used for imposing boundary conditions of 3D CFD.
NEW & NOTEWORTHY
A one-dimensional (1D) computational fluid dynamics (CFD) model for airway resistance and lung compliance was introduced to examine the relationship between airway resistance, pressure, and regional flow distribution. The 1D CFD model investigated differences of flow structure, lung hysteresis, and pressure distribution for healthy and asthmatic subjects. The derived flow distribution could be used for imposing boundary conditions of three-dimensional CFD.
Details
- Title: Subtitle
- 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs
- Creators
- Sanghun Choi - Kyungpook National UniversitySujin Yoon - Kyungpook National UniversityJichan Jeon - Kyungpook National UniversityChunrui Zou - University of IowaJiwoong Choi - University of IowaMerryn H Tawhai - University of AucklandEric A Hoffman - University of IowaRenishkumar Delvadia - Center for Drug Evaluation and ResearchAndrew Babiskin - Center for Drug Evaluation and ResearchRoss Walenga - Center for Drug Evaluation and ResearchChing-Long Lin - Department of Mechanical Engineering
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.127(1), pp.122-133
- DOI
- 10.1152/japplphysiol.00016.2019
- PMID
- 31095459
- PMCID
- PMC6692748
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- American Physiological Society
- Grant note
- U01-FD005837 / ; ; U01-HL114494; S10-RR022421 / ; XSEDE-MCA07S015 / ; KSC-2018-C2-0030; KSC-2018-CHA-0070 / ; ; NRF-2017R1D1A1B03034157 / ; ;
- Alternative title
- 1D NETWORK CFD MODEL
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984195067102771
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