Journal article
1g VH-Dependent Interaction Between Immunoglobulins and CD4
International reviews of immunology, Vol.14(4), pp.351-362
1997
DOI: 10.3109/08830189709116525
Abstract
CD4 interacts with the immunoglobulin (Ig)-VH domains by a virtue of its solvent-exposed C and C strands. These two strands also contribute to the full HIV-gp120 binding and participate significantly in binding to class IIMHC molecules. In this paper we hypothesize that any high-affinity interaction between serum (or membrane-expressed) lg and CD4 may have impact on early T cell activation events. The existing data provide evidence for different outcomes of a high affinity Ig/CD4 interaction on T cell proliferation and cytokine secretion: costimulation and inhibition. We will also discuss how a low affinity CD4/Ig interaction could play an important role in B cell stimulation initiated through surface lg receptors, and how CD4 may be involved in shaping the B cell repertoire.
Details
- Title: Subtitle
- 1g VH-Dependent Interaction Between Immunoglobulins and CD4
- Creators
- Petar Lenert - Université de MontréalGordana Lenert - Université de MontréalMaurizio Zanetti - Université de Montréal
- Resource Type
- Journal article
- Publication Details
- International reviews of immunology, Vol.14(4), pp.351-362
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/08830189709116525
- ISSN
- 0883-0185
- eISSN
- 1563-5244
- Language
- English
- Date published
- 1997
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984359911502771
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