2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres

J.A Jacobus; S Flor; A.J Klingelhutz; L.W Robertson; G Ludewig

doi:10.1016/j.etap.2007.10.022

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2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres

Journal article

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2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres

J.A Jacobus, S Flor, A.J Klingelhutz, L.W Robertson and G Ludewig

Environmental toxicology and pharmacology, Vol.25(2), pp.267-272

2008

DOI: 10.1016/j.etap.2007.10.022

PMCID: PMC2346440

PMID: 18438462

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http://doi.org/10.1016/j.etap.2007.10.022View

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Abstract

The toxicity of polychlorinated biphenyls (PCBs) has been attributed widely to receptor-mediated effects, buttressed by the popularity of the toxic equivalency factor. We propose that a crucial toxic mechanism of lower chlorinated PCBs is their enzymatic biotransformation to electrophiles, including quinoid metabolites, that bind intracellular sulfhydryl groups, such as those found in microtubulin and enzymes like telomerase. To test this hypothesis, we have examined micronuclei induction, cell cycle, and telomere shortening in cells in culture. Our findings show a large increase in micronuclei frequency and cell cycle perturbation in V79 cells, and a marked decrease in telomere length in HaCaT cells exposed to 2-(4′-chlorophenyl)-1,4-benzoquinone (PCB3pQ).

Sulfhydryl binding

Telomere shortening

DNA

PCB

Micronucleus

Details

Title: Subtitle: 2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres
Creators: J.A Jacobus - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus # 124 IREH, Iowa City, IA 52242-5000, USA
S Flor - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus # 124 IREH, Iowa City, IA 52242-5000, USA
A.J Klingelhutz - Department of Microbiology, University of Iowa, USA
L.W Robertson - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus # 124 IREH, Iowa City, IA 52242-5000, USA
G Ludewig - Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus # 124 IREH, Iowa City, IA 52242-5000, USA
Resource Type: Journal article
Publication Details: Environmental toxicology and pharmacology, Vol.25(2), pp.267-272
DOI: 10.1016/j.etap.2007.10.022
PMID: 18438462
PMCID: PMC2346440
NLM abbreviation: Environ Toxicol Pharmacol
ISSN: 1382-6689
eISSN: 1872-7077
Publisher: Elsevier B.V
Language: English
Date published: 2008
Academic Unit: Microbiology and Immunology; Occupational and Environmental Health; Radiation Oncology; Iowa Superfund Research Program
Record Identifier: 9983997316302771

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