2-D pattern of nerve fiber bundles in glaucoma emerging from spectral-domain optical coherence tomography

Mona K Garvin; Michael D Abràmoff; Kyungmoo Lee; Meindert Niemeijer; Milan Sonka; Young H Kwon

doi:10.1167/iovs.11-8349

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2-D pattern of nerve fiber bundles in glaucoma emerging from spectral-domain optical coherence tomography

Journal article

Open access

Peer reviewed

2-D pattern of nerve fiber bundles in glaucoma emerging from spectral-domain optical coherence tomography

Mona K Garvin, Michael D Abràmoff, Kyungmoo Lee, Meindert Niemeijer, Milan Sonka and Young H Kwon

Investigative ophthalmology & visual science, Vol.53(1), pp.483-489

01/31/2012

DOI: 10.1167/iovs.11-8349

PMCID: PMC3292380

PMID: 22222272

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Abstract

To correlate the thicknesses of focal regions of the macular ganglion cell layer with those of the peripapillary nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in glaucoma subjects. Macula and optic nerve head SD-OCT volumes were obtained in 57 eyes of 57 subjects with open-angle glaucoma or glaucoma suspicion. Using a custom automated computer algorithm, the thickness of 66 macular ganglion cell layer regions and the thickness of 12 peripapillary nerve fiber layer regions were measured from registered SD-OCT volumes. The mean thickness of each ganglion cell layer region was correlated to the mean thickness of each peripapillary nerve fiber layer region across subjects. Each ganglion cell layer region was labeled with the peripapillary nerve fiber layer region with the highest correlation using a color-coded map. The resulting color-coded correlation map closely resembled the nerve fiber bundle (NFB) pattern of retinal ganglion cells. The mean r(2) value across all local macular-peripapillary correlations was 0.49 (± 0.11). When separately analyzing the 30 glaucoma subjects from the 27 glaucoma-suspect subjects, the mean r(2) value across all local macular-peripapillary correlations was significantly larger in the glaucoma group (0.56 ± 0.13 vs. 0.37 ± 0.11; P < 0.001). A two-dimensional (2-D) spatial NFB map of the retina can be developed using structure-structure relationships from SD-OCT. Such SD-OCT-based NFB maps may enhance glaucoma detection and contribute to monitoring change in the future.

Nerve Fibers - pathology

Optic Nerve - pathology

Reproducibility of Results

Prospective Studies

Follow-Up Studies

Humans

Middle Aged

Glaucoma, Open-Angle - diagnosis

Male

Tomography, Optical Coherence - methods

Visual Acuity

Low Tension Glaucoma - diagnosis

Retinal Ganglion Cells - pathology

Image Processing, Computer-Assisted

Visual Fields

Female

Details

Title: Subtitle: 2-D pattern of nerve fiber bundles in glaucoma emerging from spectral-domain optical coherence tomography
Creators: Mona K Garvin - Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, Iowa, USA. mona-garvin@uiowa.edu
Michael D Abràmoff
Kyungmoo Lee
Meindert Niemeijer
Milan Sonka
Young H Kwon
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.53(1), pp.483-489
DOI: 10.1167/iovs.11-8349
PMID: 22222272
PMCID: PMC3292380
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: R01 EB004640 / NIBIB NIH HHS R01 EY019112-01A2 / NEI NIH HHS R01 EY018853 / NEI NIH HHS R01 EY019112-02 / NEI NIH HHS R01 EY019112 / NEI NIH HHS R01 EY019112-03 / NEI NIH HHS
Language: English
Date published: 01/31/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9983806285902771

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