2009 pandemic influenza A (H1N1) and vaccine failure in pregnancy

Janice K Louie; Debra A Wadford; Agnes Norman; Denise J Jamieson

doi:10.1097/AOG.0b013e3181fd2e38

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2009 pandemic influenza A (H1N1) and vaccine failure in pregnancy

Journal article

Peer reviewed

2009 pandemic influenza A (H1N1) and vaccine failure in pregnancy

Janice K Louie, Debra A Wadford, Agnes Norman and Denise J Jamieson

Obstetrics and gynecology (New York. 1953), Vol.117(2 Pt 2), pp.470-472

02/2011

DOI: 10.1097/AOG.0b013e3181fd2e38

PMID: 21252793

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Abstract

Emerging data suggest that pregnancy conveys high risk for severe complications from the 2009 pandemic influenza A virus (2009 H1N1) infection. We describe an infected pregnant woman with critical illness owing to acute respiratory distress syndrome despite previous vaccination. Early serologic testing indicated absent immunity, followed 11 days later by a robust immune response. The patient required mechanical ventilation for 11 days, but ultimately improved, and was discharged home on hospital day 14. With the expectation that 2009 H1N1 will continue to cause disease in the immediate future, the virus has been included as a component of the 2010-2011 seasonal influenza vaccine. Vaccination of pregnant women is strongly encouraged. However, regardless of vaccination history, clinicians should remain vigilant for 2009 H1N1 infection when the virus is in circulation, and should not delay antiviral treatment of pregnant women with suspected influenza.

Adult

Antiviral Agents - therapeutic use

Cesarean Section

Female

Humans

Infant, Newborn

Influenza A Virus, H1N1 Subtype - immunology

Influenza Vaccines - administration & dosage

Influenza Vaccines - immunology

Influenza, Human - complications

Influenza, Human - epidemiology

Influenza, Human - prevention & control

Oseltamivir - therapeutic use

Pandemics - prevention & control

Pregnancy

Pregnancy Complications, Infectious - diagnosis

Pregnancy Complications, Infectious - epidemiology

Pregnancy Complications, Infectious - prevention & control

Pregnancy Complications, Infectious - virology

Respiration, Artificial

Respiratory Distress Syndrome - diagnosis

Respiratory Distress Syndrome - therapy

Respiratory Distress Syndrome - virology

Treatment Failure

Details

Title: Subtitle: 2009 pandemic influenza A (H1N1) and vaccine failure in pregnancy
Creators: Janice K Louie - Centers for Disease Control and Prevention
Debra A Wadford - California Department of Health Care Services
Agnes Norman - National Center for Chronic Disease Prevention and Health Promotion
Denise J Jamieson
Resource Type: Journal article
Publication Details: Obstetrics and gynecology (New York. 1953), Vol.117(2 Pt 2), pp.470-472
DOI: 10.1097/AOG.0b013e3181fd2e38
PMID: 21252793
ISSN: 0029-7844
eISSN: 1873-233X
Language: English
Date published: 02/2011
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446425202771

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3 Times Cited - Web of Science