2019 ASCCP Risk-Based Management Consensus Guidelines: Methods for Risk Estimation, Recommended Management, and Validation

Li C. Cheung; Didem Egemen; Xiaojian Chen; Hormuzd A. Katki; Maria Demarco; Amy L. Wiser; Rebecca B. Perkins; Richard S. Guido; Nicolas Wentzensen; Mark Schiffman

doi:10.1097/LGT.0000000000000528

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2019 ASCCP Risk-Based Management Consensus Guidelines: Methods for Risk Estimation, Recommended Management, and Validation

Journal article

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2019 ASCCP Risk-Based Management Consensus Guidelines: Methods for Risk Estimation, Recommended Management, and Validation

Li C. Cheung, Didem Egemen, Xiaojian Chen, Hormuzd A. Katki, Maria Demarco, Amy L. Wiser, Rebecca B. Perkins, Richard S. Guido, Nicolas Wentzensen and Mark Schiffman

Journal of lower genital tract disease, Vol.24(2), pp.90-101

04/01/2020

DOI: 10.1097/LGT.0000000000000528

PMID: 32243306

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Abstract

Objective To manage cervical screening abnormalities, the 2019 ASCCP management consensus guidelines will recommend clinical action on the basis of risk of cervical precancer and cancer. This article details the methods used to estimate risk, to determine the risk-based management, and to validate that the risk-based recommendations are of general use in different settings. Methods Based on 1.5 million patients undergoing triennial cervical screening by cotesting at the Kaiser Permanente Northern California from 2003 to 2017, we estimated risk profiles for different clinical scenarios and combinations of past and current human papillomavirus and cytology test results. We validated the recommended management by comparing with the estimated risks in several external data sources. Results Risk and management tables are presented separately by Egemen et al.1 and Demarco et al.2 Risk-based management derived from the Kaiser Permanente Northern California largely agreed with the management implied from the estimated risks of the other data sources. Conclusions The new risk-based guidelines present management of abnormal cervical screening results. By describing the steps used to develop these guidelines, the methods presented in this article can provide a basis for future extensions of the risk-based guidelines.

cervix

HPV

portability

risk estimation

risk-based management

screening

validation

Details

Title: Subtitle: 2019 ASCCP Risk-Based Management Consensus Guidelines: Methods for Risk Estimation, Recommended Management, and Validation
Creators: Li C. Cheung - National Cancer Institute
Didem Egemen - National Cancer Institute
Xiaojian Chen - National Cancer Institute
Hormuzd A. Katki - National Cancer Institute
Maria Demarco - National Institutes of Health
Amy L. Wiser - Oregon Health & Science University
Rebecca B. Perkins - Boston University
Richard S. Guido - University of Pittsburgh
Nicolas Wentzensen - National Institutes of Health
Mark Schiffman - National Cancer Institute
Resource Type: Journal article
Publication Details: Journal of lower genital tract disease, Vol.24(2), pp.90-101
DOI: 10.1097/LGT.0000000000000528
PMID: 32243306
NLM abbreviation: J Low Genit Tract Dis
ISSN: 1089-2591
eISSN: 1526-0976
Number of pages: 12
Grant note: National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) US National Institutes of Health/National Cancer Institute
Language: English
Date published: 04/01/2020
Academic Unit: Family and Community Medicine
Record Identifier: 9985134036202771

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