2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes

Eric Uwimana; Xueshu Li; Hans-Joachim Lehmler

doi:10.1021/acs.chemrestox.6b00371

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2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes

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2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes

Eric Uwimana, Xueshu Li and Hans-Joachim Lehmler

Chemical research in toxicology, Vol.29(12), pp.2108-2110

12/19/2016

DOI: 10.1021/acs.chemrestox.6b00371

PMCID: PMC5175585

PMID: 27989147

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Abstract

Exposure to neurotoxic, chiral PCBs has been associated with neurodevelopmental disorders, but their metabolism in humans remains unexplored. We investigated the enantioselective metabolism of PCB 95 by human liver microsomes (HLMs) to potentially neurotoxic, hydroxylated metabolites (OH-PCBs). OH-PCB profiles formed in experiments with HLMs differed from metabolite profiles reported for rodent species. The second eluting atropisomer of 2,2',3,5',6-pentachlorobiphenyl-4'-ol, the major metabolite, was preferentially formed by all HLM preparations investigated. Differences in metabolite formation rates were observed with single donor HLMs. The metabolism of PCBs and its role in PCB-mediated neurodevelopmental disorders need to be further characterized.

Polychlorinated Biphenyls - metabolism

Hydroxylation

Humans

Microsomes, Liver - metabolism

ISRP Projects 3 2015-2020

ISRP Project 5 2015-2020

Synthesis Core

Details

Title: Subtitle: 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes
Creators: Eric Uwimana - Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, University of Iowa , Iowa City, Iowa 52242, United States
Xueshu Li - Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, University of Iowa , Iowa City, Iowa 52242, United States
Hans-Joachim Lehmler - Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, University of Iowa , Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: Chemical research in toxicology, Vol.29(12), pp.2108-2110
DOI: 10.1021/acs.chemrestox.6b00371
PMID: 27989147
PMCID: PMC5175585
NLM abbreviation: Chem Res Toxicol
ISSN: 0893-228X
eISSN: 1520-5010
Publisher: United States
Grant note: P42 ES013661 / NIEHS NIH HHS P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 12/19/2016
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
Record Identifier: 9984001081802771

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