2,3-methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution

Dongyeol Lim; Destardi Moye-Sherman; Inhye Ham; Song Jin; J Martin Scholtz; Kevin Burgess

doi:10.1039/a805367g

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2,3-methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution

Journal article

Peer reviewed

2,3-methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution

Dongyeol Lim, Destardi Moye-Sherman, Inhye Ham, Song Jin, J Martin Scholtz and Kevin Burgess

Chemical communications (Cambridge, England), Vol.1998(21), pp.2375-2376

11/07/1998

DOI: 10.1039/a805367g

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Abstract

Peptidomimetics 1 and 2 of RN24 (an RNase A C-peptide analog) in which the Arg(+)-10 residue is replaced by 2R,3S-cyclo-Arg' and by 2S,3S-cyclo-Arg', respectively, show less temperature dependence in CD studies than the parent peptide.

Physical Sciences

Chemistry

Chemistry, Multidisciplinary

Science & Technology

Details

Title: Subtitle: 2,3-methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution
Creators: Dongyeol Lim
Destardi Moye-Sherman - Mitchell Institute
Inhye Ham
Song Jin
J Martin Scholtz
Kevin Burgess
Resource Type: Journal article
Publication Details: Chemical communications (Cambridge, England), Vol.1998(21), pp.2375-2376
DOI: 10.1039/a805367g
NLM abbreviation: Chem Commun (Camb)
ISSN: 1359-7345
eISSN: 1364-548X
Publisher: Royal Society of Chemistry
Number of pages: 2
Language: English
Date published: 11/07/1998
Academic Unit: Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Biochemistry and Molecular Biology; Chemistry
Record Identifier: 9984288716202771

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