Journal article
24‐hour activity cycle behaviors and gray matter volume in mild cognitive impairment
Alzheimer's & dementia, Vol.21(7), e70496
07/2025
DOI: 10.1002/alz.70496
PMCID: PMC12281022
PMID: 40693459
Abstract
INTRODUCTION
The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume.
METHODS
Cross-sectional study in 110 adults with MCI. Actigraphy assessed 24-HAC behaviors. FreeSurfer quantified GM. Compositional linear regressions and isotemporal substitution determined 24-HAC composition and GM volume associations.
RESULTS
Higher moderate-to-vigorous physical activity (MVPA) relative to remaining behaviors was associated with greater right inferior temporal gyrus volume (ß = 0.30, false-discovery rate (FDR)-corrected-p = 0.030). Higher SB relative to remaining behaviors was associated with lower volume in the same region (ß = −0.45, FDR-corrected-p = 0.015). Reallocating 30 min from SB to MVPA predicted 2.1% greater (ß = 0.06, p < 0.001) and from MVPA to SB predicted 2.8% lower volume (ß = −0.08, p < 0.001).
DISCUSSION
Increasing MVPA at the expense of SB may protect GM in regions prone to Alzheimer's disease-related atrophy.
TRIAL REGISTRATIONS
ClinicalTrials.gov, NCT02926157, NCT02737878, and NCT02669394.
Details
- Title: Subtitle
- 24‐hour activity cycle behaviors and gray matter volume in mild cognitive impairment
- Creators
- Guilherme Moraes Balbim - Vancouver Coastal Health Research InstituteNárlon C. Boa Sorte Silva - Concordia UniversityRyan S. Falck - University of British ColumbiaArthur F. Kramer - Northeastern UniversityMichelle W. Voss - University of IowaTeresa Liu-Ambrose - University of British Columbia
- Resource Type
- Journal article
- Publication Details
- Alzheimer's & dementia, Vol.21(7), e70496
- DOI
- 10.1002/alz.70496
- PMID
- 40693459
- PMCID
- PMC12281022
- NLM abbreviation
- Alzheimers Dement
- ISSN
- 1552-5260
- eISSN
- 1552-5279
- Publisher
- John Wiley and Sons Inc
- Grant note
- ; AWD‐ 016347; MOP‐142206; PJT‐148902 / ; G‐15‐0009019 / ; F16‐01717 / ;
- Language
- English
- Date published
- 07/2025
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984865314702771
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