25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice

E Danielle Dean; Lydia M Mexas; Natalie L Cápiro; Jeanne E McKeon; Mahlon R DeLong; Kurt D Pennell; Jonathan A Doorn; Vin Tangpricha; Gary W Miller; Marian L Evatt

doi:10.1371/journal.pone.0039227

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25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice

Journal article

Open access

Peer reviewed

25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice

E Danielle Dean, Lydia M Mexas, Natalie L Cápiro, Jeanne E McKeon, Mahlon R DeLong, Kurt D Pennell, Jonathan A Doorn, Vin Tangpricha, Gary W Miller and Marian L Evatt

PloS one, Vol.7(7), pp.e39227-e39227

2012

DOI: 10.1371/journal.pone.0039227

PMCID: PMC3388077

PMID: 22768297

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Abstract

Recent clinical evidence supports a link between 25-hydroxyvitamin D insufficiency (serum 25-hydroxyvitamin D [25(OH)D] levels <30 ng/mL) and Parkinson's disease. To investigate the effect of 25(OH)D depletion on neuronal susceptibility to toxic insult, we induced a state of 25(OH)D deficiency in mice and then challenged them with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We found there was no significant difference between control and 25(OH)D-deficient animals in striatal dopamine levels or dopamine transporter and tyrosine hydroxylase expression after lesioning with MPTP. Additionally, we found no difference in tyrosine hydroxylase expression in the substantia nigra pars compacta. Our data suggest that reducing 25(OH)D serum levels in mice has no effect on the vulnerability of nigral dopaminergic neurons in vivo in this model system of parkinsonism.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology

Dopamine Plasma Membrane Transport Proteins - metabolism

Tyrosine 3-Monooxygenase - metabolism

Substantia Nigra - pathology

Dopaminergic Neurons - pathology

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects

Neurotoxins - adverse effects

Male

Substantia Nigra - metabolism

Corpus Striatum - metabolism

Nerve Tissue Proteins - metabolism

Neurotoxins - pharmacology

Animals

MPTP Poisoning - metabolism

Dopaminergic Neurons - metabolism

MPTP Poisoning - pathology

Vitamin D - analogs & derivatives

Vitamin D - metabolism

Mice

Corpus Striatum - pathology

Details

Title: Subtitle: 25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice
Creators: E Danielle Dean - Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Lydia M Mexas
Natalie L Cápiro
Jeanne E McKeon
Mahlon R DeLong
Kurt D Pennell
Jonathan A Doorn
Vin Tangpricha
Gary W Miller
Marian L Evatt
Resource Type: Journal article
Publication Details: PloS one, Vol.7(7), pp.e39227-e39227
DOI: 10.1371/journal.pone.0039227
PMID: 22768297
PMCID: PMC3388077
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library Science; United States
Grant note: P01 ES 016731 / NIEHS NIH HHS K23 AR054334 / NIAMS NIH HHS T32 ES012870 / NIEHS NIH HHS T32 ES 012870 / NIEHS NIH HHS P01 ES016731 / NIEHS NIH HHS
Language: English
Date published: 2012
Academic Unit: Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
Record Identifier: 9984070118502771

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