Journal article
2D CAIPI accelerated 3D multi-slab diffusion weighted EPI combined with qModeL reconstruction for fast high resolution microstructure imaging
Magnetic resonance imaging, Vol.111, pp.57-66
09/2024
DOI: 10.1016/j.mri.2024.04.003
PMCID: PMC11179987
PMID: 38599504
Abstract
To develop acceleration strategies for 3D multi-slab diffusion weighted imaging (3D ms-DWI) for enabling applications that require simultaneously high spatial (1 mm isotropic) and angular (> 30 directions) resolution.
3D ms-DWI offers high SNR-efficiency, with the ability to achieve high isotropic spatial resolution, yet suffers from long scan-times for studies requiring high angular resolutions. We develop 6D k-q space acceleration strategies to reduce the scan-time. Specifically, we develop non-uniform 3D k
-k
under-sampling employing a shot-selective 2D CAIPI sampling approach. To achieve inter-shot phase-compensation, 2D navigators were employed that utilize the same CAIPI trajectory. An iterative model-based 3D multi-shot reconstruction was designed by incorporating phase into the forward encoding process. Additionally, the shot-selective non-uniform k
-k
CAIPI acceleration was randomized along the q-dimension. The 3D model-based multi-shot reconstruction is then extended to a joint reconstruction that simultaneously reconstructs all the q-space points, with the help of a spatial total variation and deep-learned q-space regularization.
The proposed reconstruction is shown to achieve adequate phase-compensation in both 2D CAIPI accelerated and additional k
-k
under-sampled cases. Using retrospective under-sampling experiments, we show that k-q accelerations close a factor of 12 can be achieved with reconstruction error < 3% for both single and multi-shell data. This translates to a scan-time reduction by 3-fold for experiments with simultaneously high spatial and angular resolution.
The proposed method facilitates the utilization of 3D ms-DWI for simultaneously high k-q resolution applications with close to 3× reduced scan-time.
Details
- Title: Subtitle
- 2D CAIPI accelerated 3D multi-slab diffusion weighted EPI combined with qModeL reconstruction for fast high resolution microstructure imaging
- Creators
- Chu-Yu Lee - Department of Radiology, University of Iowa, Iowa City, IA, United States of AmericaMerry Mani - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance imaging, Vol.111, pp.57-66
- DOI
- 10.1016/j.mri.2024.04.003
- PMID
- 38599504
- PMCID
- PMC11179987
- NLM abbreviation
- Magn Reson Imaging
- ISSN
- 0730-725X
- eISSN
- 1873-5894
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 EB031169-02S1, 1S10RR028821-01, 1S10OD030220-01, 1S10OD025025-01
- Language
- English
- Electronic publication date
- 04/08/2024
- Date published
- 09/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984584903402771
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