Journal article
3’-deoxy-3’-[18F]fluorothymidine PET Quantification of Bone Marrow Response to Radiation Dose
International journal of radiation oncology, biology, physics, Vol.81(3), pp.888-893
11/01/2011
DOI: 10.1016/j.ijrobp.2010.12.009
PMID: 21300484
Abstract
The purpose of this study was to quantify the relationship of bone marrow response to radiation dose, using 3’-deoxy-3’-[18F]fluorothymidine ([18F]FLT)-labeled uptake quantified in positron-emission tomography (PET) scans.
Pre- and post-Week 1 treatment [18F]FLT PET images were registered to the CT images used to create the radiation treatment plan. Changes in [18F]FLT uptake values were measured using profile data of standardized uptake values (SUVs) and doses along the vertebral bodies located at a field border where a range of radiation doses were present for 10 patients. Data from the profile measurements were grouped into 1 Gy dose bins from 1 to 9 Gy to compare SUV changes for all patients. Additionally, the maximum pretreatment, the post-Week 1 treatment, and the dose values located within the C6–T7 vertebrae that straddled the field edge were measured for all patients.
Both the profile and the individual vertebral data showed a strong correlation between SUV change and radiation dose. Relative differences in SUVs between bins >1 Gy and <7 Gy were statistically significant (p < 0.01, two-sample t test). The reduction in SUV was approximately linear until it reached a reduction threshold of 75%–80% in SUV for doses greater than 6 Gy/week for both the dose-binned data and the vertebral maximum SUVs.
The change in SUV observed in head and neck cancer patients treated with chemoradiation shows the potential for using [18F]FLT PET images for identifying active bone marrow and monitoring changes due to radiation dose. Additionally, the change in [18F]FLT uptake observed in bone marrow for different weekly doses suggests potential dose thresholds for reducing bone marrow toxicity.
Details
- Title: Subtitle
- 3’-deoxy-3’-[18F]fluorothymidine PET Quantification of Bone Marrow Response to Radiation Dose
- Creators
- Sarah M McGuire - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242Yusuf Menda - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242Laura L Boles Ponto - Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242Brandie Gross - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242John Buatti - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242John E Bayouth - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.81(3), pp.888-893
- DOI
- 10.1016/j.ijrobp.2010.12.009
- PMID
- 21300484
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 11/01/2011
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040361302771
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