Journal article
3D Bioprinting: from Benches to Translational Applications
Small (Weinheim an der Bergstrasse, Germany), Vol.15(23), pp.e1805510-e1805510
04/29/2019
DOI: 10.1002/smll.201805510
PMCID: PMC6752725
PMID: 31033203
Abstract
Over the last decades, the fabrication of three-dimensional (3D) tissues has become commonplace in tissue engineering and regenerative medicine. However, conventional 3D fabrication techniques such as scaffolding, microengineering, and fiber and cell sheet engineering are limited in their capacity to fabricate complex tissue constructs with the required precision and controllability that is needed to replicate biologically relevant tissues. To this end, 3D bioprinting offers great versatility to fabricate biomimetic volumetric tissues that are structurally and functionally relevant. It enables precise control of the composition, spatial distribution, and architecture of bioprinted constructs facilitating the recapitulation of the delicate shape and structure of targeted organs and tissues. Here we systematically review the history of bioprinting and the most recent advances in instrumentation and methods. We then focus on the requirements for bioinks and cells to achieve optimal fabrication of biomimetic constructs. We next discuss emerging evolutions and future directions of bioprinting such as freeform, high-resolution, multi-material, and four-dimensional bioprinting. Finally, we present the translational potential of bioprinting and bioprinted tissues of various categories and conclude by exemplifying commercially available bioprinting platforms.
Recent advances in translating 3D bioprinting to the clinics are reviewed, including developments in bioprinting strategies, innovations in bioinks for bioprinting, advances in bioprinting of complex architectures, and translational potential of bioprinted tissue-like structures. Commercially available bioprinting platforms are briefly discussed towards the end.
Details
- Title: Subtitle
- 3D Bioprinting: from Benches to Translational Applications
- Creators
- Marcel Alexander Heinrich - University of TwenteWanjun Liu - Donghua UniversityAndrea Jimenez - Harvard UniversityJingzhou Yang - Harvard UniversityAli Akpek - Gebze Technical UniversityXiao Liu - Beihang UniversityQingmeng Pi - Shanghai Jiao Tong UniversityXuan Mu - Brigham and Women's HospitalNing Hu - Harvard UniversityRaymond Michel Schiffelers - Utrecht UniversityJai Prakash - University of TwenteJingwei Xie - University of Nebraska Medical CenterYu Shrike Zhang - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), Vol.15(23), pp.e1805510-e1805510
- DOI
- 10.1002/smll.201805510
- PMID
- 31033203
- PMCID
- PMC6752725
- ISSN
- 1613-6810
- eISSN
- 1613-6829
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: K99CA201603, R21EB025270, R21EB026175
- Language
- English
- Date published
- 04/29/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984276458202771
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