Journal article
3D Bioprinting in Otolaryngology: A Review
Advanced healthcare materials, Vol.12(19), 2203268
07/27/2023
DOI: 10.1002/adhm.202203268
PMCID: PMC10502192
PMID: 36921327
Appears in UI Libraries Support Open Access
Abstract
The evolution of tissue engineering and 3D bioprinting has allowed for increased opportunities to generate musculoskeletal tissue grafts that can enhance functional and aesthetic outcomes in otolaryngology- head and neck surgery. Despite literature reporting successes in the fabrication of cartilage and bone scaffolds for applications in the head and neck, the full potential of this technology has yet to be realized. Otolaryngology as a field has always been at the forefront of new advancements and technology and is well poised to spearhead clinical application of these engineered tissues. In this review, we describe current 3D bioprinting methods and present an overview of potential cell types, bioinks, and bioactive factors available for musculoskeletal engineering using this technology. We review the otologic, nasal, tracheal, and craniofacial bone applications of 3D bioprinting with a focus on engineered graft implantation in animal models to highlight the status of functional outcomes in vivo; a necessary step to future clinical translation. Continued multidisciplinary efforts between material chemistry, biological sciences, and otolaryngologists will play a key in role in the translation of engineered, 3D bioprinted constructs for head and neck surgery. This article is protected by copyright. All rights reserved.
Details
- Title: Subtitle
- 3D Bioprinting in Otolaryngology: A Review
- Creators
- Alexandra McMillan - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USANadia McMillan - Beth Israel Deaconess Medical CenterNikesh Gupta - University of IowaSohit P Kanotra - University of IowaAliasger K Salem - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Advanced healthcare materials, Vol.12(19), 2203268
- DOI
- 10.1002/adhm.202203268
- PMID
- 36921327
- PMCID
- PMC10502192
- NLM abbreviation
- Adv Healthc Mater
- ISSN
- 2192-2640
- eISSN
- 2192-2659
- Publisher
- Wiley
- Language
- English
- Electronic publication date
- 03/15/2023
- Date published
- 07/27/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Otolaryngology
- Record Identifier
- 9984378114002771
Metrics
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