Journal article
3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures
Advanced materials (Weinheim), Vol.30(14), pp.e1707196-9
04/2018
DOI: 10.1002/adma.201707196
PMCID: PMC6112611
PMID: 29484715
Abstract
The advent of adaptive manufacturing techniques supports the vision of cell-instructive materials that mimic biological tissues. 3D jet writing, a modified electrospinning process reported herein, yields 3D structures with unprecedented precision and resolution offering customizable pore geometries and scalability to over tens of centimeters. These scaffolds support the 3D expansion and differentiation of human mesenchymal stem cells in vitro. Implantation of these constructs leads to the healing of critical bone defects in vivo without exogenous growth factors. When applied as a metastatic target site in mice, circulating cancer cells home in to the osteogenic environment simulated on 3D jet writing scaffolds, despite implantation in an anatomically abnormal site. Through 3D jet writing, the formation of tessellated microtissues is demonstrated, which serve as a versatile 3D cell culture platform in a range of biomedical applications including regenerative medicine, cancer biology, and stem cell biotechnology.
Details
- Title: Subtitle
- 3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures
- Creators
- Jacob H Jordahl - BioSurfacesLuis Solorio - BioSurfacesHongli Sun - BioSurfacesStacy Ramcharan - BioSurfacesClark B Teeple - BioSurfacesHenry R Haley - Biointerfaces Institute, NCRC B10-A175, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USAKyung Jin Lee - Biointerfaces Institute, NCRC B10-A175, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USAThomas W Eyster - BioSurfacesGary D Luker - BioSurfacesPaul H Krebsbach - BioSurfacesJoerg Lahann - BioSurfaces
- Resource Type
- Journal article
- Publication Details
- Advanced materials (Weinheim), Vol.30(14), pp.e1707196-9
- DOI
- 10.1002/adma.201707196
- PMID
- 29484715
- PMCID
- PMC6112611
- NLM abbreviation
- Adv Mater
- ISSN
- 0935-9648
- eISSN
- 1521-4095
- Grant note
- R00 CA198929 / NCI NIH HHS U01 CA210152 / NCI NIH HHS
- Language
- English
- Date published
- 04/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9984367750702771
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