3D Printing of Monolithic Proteinaceous Cantilevers Using Regenerated Silk Fibroin

Xuan Mu; Constancio Gonzalez-Obeso; Zhiyu Xia; Jugal Kishore Sahoo; Gang Li; Peggy Cebe; Yu Shrike Zhang; David L. Kaplan

doi:10.3390/molecules27072148

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3D Printing of Monolithic Proteinaceous Cantilevers Using Regenerated Silk Fibroin

Journal article

Open access

Peer reviewed

3D Printing of Monolithic Proteinaceous Cantilevers Using Regenerated Silk Fibroin

Xuan Mu, Constancio Gonzalez-Obeso, Zhiyu Xia, Jugal Kishore Sahoo, Gang Li, Peggy Cebe, Yu Shrike Zhang and David L. Kaplan

Molecules (Basel, Switzerland), Vol.27(7), p.2148

04/01/2022

DOI: 10.3390/molecules27072148

PMCID: PMC9000323

PMID: 35408547

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https://doi.org/10.3390/molecules27072148View

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Abstract

Silk fibroin, regenerated from Bombyx mori, has shown considerable promise as a printable, aqueous-based ink using a bioinspired salt-bath system in our previous work. Here, we further developed and characterized silk fibroin inks that exhibit concentration-dependent fluorescence spectra at the molecular level. These insights supported extrusion-based 3D printing using concentrated silk fibroin solutions as printing inks. 3D monolithic proteinaceous structures with high aspect ratios were successfully printed using these approaches, including cantilevers only supported at one end. This work provides further insight and broadens the utility of 3D printing with silk fibroin inks for the microfabrication of proteinaceous structures.

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

Details

Title: Subtitle: 3D Printing of Monolithic Proteinaceous Cantilevers Using Regenerated Silk Fibroin
Creators: Xuan Mu - Tufts University
Constancio Gonzalez-Obeso - Tufts University
Zhiyu Xia - Tufts University
Jugal Kishore Sahoo - Tufts University
Gang Li - Tufts University
Peggy Cebe - Tufts University
Yu Shrike Zhang - Brigham and Women's Hospital
David L. Kaplan - Tufts University
Resource Type: Journal article
Publication Details: Molecules (Basel, Switzerland), Vol.27(7), p.2148
DOI: 10.3390/molecules27072148
PMID: 35408547
PMCID: PMC9000323
NLM abbreviation: Molecules
ISSN: 1420-3049
eISSN: 1420-3049
Publisher: Mdpi
Number of pages: 12
Grant note: DMR-2003629 / NSF; National Science Foundation (NSF) W911NF2120130 / ARO FA9550-20-1-0363 / AFOSR; United States Department of Defense; Air Force Office of Scientific Research (AFOSR) P41EB027062 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Brigham Research Institute
Language: English
Date published: 04/01/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984276457502771

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