Journal article
3D hyperpolarized he-3 MRI of ventilation using a multi-echo projection acquisition
Magnetic resonance in medicine, Vol.59(5), pp.1062-1071
05/01/2008
DOI: 10.1002/mrm.21437
PMCID: PMC3001140
PMID: 18429034
Abstract
A method is presented for high-resolution 3D imaging of the whole lung using inhaled hyperpolarized (HP) He-3 MR with multiple half-echo radial trajectories that can accelerate imaging through undersampling. A multiple half-echo radial trajectory can be used to reduce the level of artifact for under-sampled 3D projection reconstruction (PR) imaging by increasing the amount of data acquired per unit time for HIP He-3 lung imaging. The point spread functions (PSFs) for breath-held He-3 MRI using multiple half-echo trajectories were evaluated using simulations to predict the effects of T-2* and gas diffusion on image quality. Results from PSF simulations were consistent with imaging results in volunteer studies showing improved image quality with increasing number of echoes using up to 8 half-echoes. The 8-half-echo acquisition is shown to accommodate lost breath-holds as short as 6 sec using a retrospective reconstruction at reduced resolution and also to allow reduced breath-hold time compared with an equivalent Cartesian trajectory. Furthermore, preliminary results from a 3D dynamic inhalation-exhalation maneuver are demonstrated using the 8-half-echo trajectory. Results demonstrate the first highresolution 3D PR imaging of ventilation and respiratory dynamics in humans using HIP He-3 MR.
Details
- Title: Subtitle
- 3D hyperpolarized he-3 MRI of ventilation using a multi-echo projection acquisition
- Creators
- James H. Holmes - University of Wisconsin–MadisonRafael L. O'Halloran - University of Wisconsin–MadisonEthan K. Brodsky - University of Wisconsin–MadisonYoungkyoo Jung - University of Wisconsin–MadisonWalter F. Block - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.59(5), pp.1062-1071
- Publisher
- Wiley
- DOI
- 10.1002/mrm.21437
- PMID
- 18429034
- PMCID
- PMC3001140
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 10
- Grant note
- T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P50 HL056396-06; P50 HL056396; 2P50 HL 56396-06 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P50HL056396 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32 CA009206; T32 CA009206-26; 2T32 CA 09206-26 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 05/01/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274952702771
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