Journal article
5-Fluoro-1-octanoyluracil
Acta crystallographica. Section C, Crystal structure communications, Vol.56(11), pp.e518-e519
11/15/2000
DOI: 10.1107/S0108270100013056
Abstract
The crystal structure of 5-fluoro-1-octanoyluracil [5-fluoro-1-octanoylpyrimidine-2,4(1H,3H)-dione, C12H17FN2O3], a lipophilic prodrug of 5-fluorouracil, is described. The 5-fluoropyrimidine-2,4(1H,3H)-dione moiety is similar to the known structure of 1-acetyl-5-fluorouracil. The 1-octanoyl group and the 5-fluorouracil moiety are essentially coplanar, with the octanoyl carbonyl group oriented towards the the ring C—H group and away from the nearer ring carbonyl group. The torsion angle C—N—C—O (from the ring CH group to the octanoyl carbonyl group) of 9.2 (2)° is similar to the corresponding torsion angles reported for 1-acetyl-5-fluorouracil (17.3 and 1.6°) and 1,3-diacetyl-5-fluorouracil (8.8°).
Details
- Title: Subtitle
- 5-Fluoro-1-octanoyluracil
- Creators
- Hans-Joachim LehmlerSean Parkin
- Resource Type
- Journal article
- Publication Details
- Acta crystallographica. Section C, Crystal structure communications, Vol.56(11), pp.e518-e519
- DOI
- 10.1107/S0108270100013056
- ISSN
- 0108-2701
- eISSN
- 1600-5759
- Language
- English
- Date published
- 11/15/2000
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute
- Record Identifier
- 9984000924302771
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