5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

Jason J RADLEY; Barry L JACOBS

doi:10.1016/S0006-8993(02)03477-7

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5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

Journal article

Peer reviewed

5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

Jason J RADLEY and Barry L JACOBS

Brain research, Vol.955(1-2), pp.264-267

2002

DOI: 10.1016/S0006-8993(02)03477-7

PMID: 12419546

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Abstract

This study investigated the action of 5-HT1A receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant ∼30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT1A receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.

Cell Physiology

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Molecular and cellular biology

Cell cycle, cell proliferation

Details

Title: Subtitle: 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
Creators: Jason J RADLEY - Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, United States
Barry L JACOBS - Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, United States
Resource Type: Journal article
Publication Details: Brain research, Vol.955(1-2), pp.264-267
Publisher: Elsevier; London; Amsterdam; New York, NY
DOI: 10.1016/S0006-8993(02)03477-7
PMID: 12419546
ISSN: 0006-8993
eISSN: 1872-6240
Language: English
Date published: 2002
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070514502771

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