Journal article
5-HT2A receptor promoter polymorphism, -1438G/A and negative symptom response to olanzapine in schizophrenia
Psychopharmacology bulletin, Vol.37(2), pp.109-112
2003
PMID: 14566219
Abstract
The 5-HT2A receptor promoter -1438G/A polymorphism, which is in complete linkage disequilibrium with the 5-HT2A 102T/C polymorphism, may be related to antipsychotic response. The aim of this paper is to determine relationships between the -1438G/A polymorphism and olanzapine negative symptom response. DNA from 41 subjects with schizophrenia (as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) was analyzed for the -1438G/A polymorphism. Olanzapine (7.5-20 mg/day) was given for 6 weeks and response was assessed using the Scale for Assessment of Negative Symptoms (SANS). A linear regression used a dependent variable of percent change in SANS. Independent variables included 5-HT2A polymorphisms and interactions. The -1438G/A polymorphism and percent change in SANS showed a significant trend (P=.0542). The A/A genotype group had a 45% reduction in SANS compared with 19% in the other groups. We conclude that the A/A genotype may be associated with olanzapine negative symptom response, seen as a 2-fold greater percent reduction in SANS, and may be clinically relevant.
Details
- Title: Subtitle
- 5-HT2A receptor promoter polymorphism, -1438G/A and negative symptom response to olanzapine in schizophrenia
- Creators
- Vicki L Ellingrod - Clinical and Administrative Division, University of Iowa College of Pharmacy, Iowa City, Iowa, USA. vicki-ellinrod@uiowa.eduBrian C LundDel MillerFrank FlemingPaul PerryTimothy L HolmanKristy Bever-Stille
- Resource Type
- Journal article
- Publication Details
- Psychopharmacology bulletin, Vol.37(2), pp.109-112
- Publisher
- United States
- PMID
- 14566219
- ISSN
- 0048-5764
- eISSN
- 2472-2448
- Language
- English
- Date published
- 2003
- Academic Unit
- Pharmacy; Psychiatry; Epidemiology
- Record Identifier
- 9984003978802771
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