7T MRI detects deterioration in subchondral bone microarchitecture in subjects with mild knee osteoarthritis as compared with healthy controls

Gregory Chang; Ding Xia; Cheng Chen; Guillaume Madelin; Steven B Abramson; James S Babb; Punam K Saha; Ravinder R Regatte

doi:10.1002/jmri.24683

Back

7T MRI detects deterioration in subchondral bone microarchitecture in subjects with mild knee osteoarthritis as compared with healthy controls

Journal article

Peer reviewed

7T MRI detects deterioration in subchondral bone microarchitecture in subjects with mild knee osteoarthritis as compared with healthy controls

Gregory Chang, Ding Xia, Cheng Chen, Guillaume Madelin, Steven B Abramson, James S Babb, Punam K Saha and Ravinder R Regatte

Journal of magnetic resonance imaging, Vol.41(5), pp.1311-1317

05/2015

DOI: 10.1002/jmri.24683

PMID: 24979471

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/9982830View

Open Access

Abstract

Purpose To determine how subchondral bone microarchitecture is altered in patients with mild knee osteoarthritis. Materials and Methods This study had Institutional Review Board approval. We recruited 24 subjects with mild radiographic knee osteoarthritis and 16 healthy controls. The distal femur was scanned at 7T using a high‐resolution 3D FLASH sequence. We applied digital topological analysis to assess bone volume fraction, markers of trabecular number (skeleton density), trabecular network osteoclastic resorption (erosion index), plate‐like structure (surface), rod‐like structure (curve), and plate‐to‐rod ratio (surface‐curve ratio). We used two‐tailed t‐tests to compare differences between osteoarthritis subjects and controls. Results 7T magnetic resonance imaging (MRI) detected deterioration in subchondral bone microarchitecture in both medial and lateral femoral condyles in osteoarthritis subjects as compared with controls. This was manifested by lower bone volume fraction (−1.03% to −5.43%, P < 0.04), higher erosion index (+8.49 to +22.76%, P < 0.04), lower surface number (−2.31% to −9.63%, P < 0.007), higher curve number (+6.85% to +16.93%, P < 0.03), and lower plate‐to‐rod ratio (−7.92% to −21.71%, P < 0.05). Conclusion The results provide further support for the concept that poor subchondral bone quality is associated with osteoarthritis and may serve as a potential therapeutic target for osteoarthritis interventions. J. Magn. Reson. Imaging 2015;41:1311–1317. © 2014 Wiley Periodicals, Inc.

bone microarchitecture

knee

osteoarthritis

Details

Title: Subtitle: 7T MRI detects deterioration in subchondral bone microarchitecture in subjects with mild knee osteoarthritis as compared with healthy controls
Creators: Gregory Chang - New York University
Ding Xia - New York University
Cheng Chen - University of Iowa
Guillaume Madelin - University of Iowa
Steven B Abramson - New York University
James S Babb - New York University
Punam K Saha - University of Iowa
Ravinder R Regatte - New York University
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.41(5), pp.1311-1317
DOI: 10.1002/jmri.24683
PMID: 24979471
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Number of pages: 7
Grant note: National Institutes of Health (NIH) (NIH K23–059748 (to G.C.), NIH RO1‐O56260 (to R.R.), NIH RO1–060238 (to R.R.))
Language: English
Date published: 05/2015
Academic Unit: Radiology; Electrical and Computer Engineering
Record Identifier: 9984197258602771

Metrics

18 Record Views

18 Times Cited - Web of Science