Journal article
7T MRI of distal radius trabecular bone microarchitecture: How trabecular bone quality varies depending on distance from end‐of‐bone
Journal of magnetic resonance imaging, Vol.45(3), pp.872-878
03/2017
DOI: 10.1002/jmri.25398
PMCID: PMC5250596
PMID: 27439146
Abstract
Purpose
To use 7T magnetic resonance imaging (MRI) to determine how trabecular bone microarchitecture varies at the epiphysis, metaphysis, and diaphysis of the distal radius.
Materials and Methods
The distal radius of 24 females (mean age = 56 years, range = 24–78 years) was scanned on a 7T MRI using a 3D fast low‐angle shot sequence (0.169 × 0.169 × 1 mm). Digital topological analysis was applied at the epiphysis, metaphysis, and diaphysis to compute: total trabecular bone volume; trabecular thickness, number, connectivity, and erosion index (a measure of network resorption). Differences and correlations were assessed using standard statistical methods.
Results
The metaphysis and epiphysis had 83–123% greater total bone volume and 14–16% greater trabecular number than the diaphysis (both P < 0.0001). The erosion index was significantly higher at the diaphysis than the metaphysis and epiphysis (both P < 0.01). The most elderly volunteers had lower trabecular number (<66 years mean 0.29 ± 0.01; ≥66 years, 0.27 ± 0.02, P < 0.05) and higher erosion index (<66 years mean 1.18 ± 0.17; age ≥66 years, mean 1.42 ± 0.46, P < 0.05) at the epiphysis; differences not detected by total trabecular bone volume.
Conclusion
7T MRI reveals trabecular bone microarchitecture varies depending on scan location at the end‐of‐bone, being of overall higher quality distally (epiphysis) than proximally (diaphysis). Age‐related differences in trabecular microarchitecture can be detected by 7T MRI. The results highlight the potential sensitivity of 7T MRI to microarchitectural differences and the potential importance of standardizing scan location for future clinical studies of fracture risk or treatment response.
Level of Evidence: 3
J. Magn. Reson. Imaging 2017;45:872–878.
Details
- Title: Subtitle
- 7T MRI of distal radius trabecular bone microarchitecture: How trabecular bone quality varies depending on distance from end‐of‐bone
- Creators
- Lindsay M Griffin - New York UniversityStephen Honig - New York UniversityCheng Chen - University of IowaPunam K Saha - University of IowaRavinder Regatte - New York UniversityGregory Chang - New York University
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.45(3), pp.872-878
- DOI
- 10.1002/jmri.25398
- PMID
- 27439146
- PMCID
- PMC5250596
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Number of pages
- 7
- Grant note
- National Institutes of Health (K23‐AR059748 ; RO1‐AR066008)
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984051739802771
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