Journal article
A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D-3 Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness
The journal of clinical endocrinology and metabolism, Vol.95(10), pp.4584-4591
10/01/2010
DOI: 10.1210/jc.2010-0606
PMID: 20660028
Abstract
Context: Vitamin D insufficiency/deficiency is commonly observed in black youth.
Objective: The aim was to determine 25-hydroxyvitamin D[25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV).
Design: We conducted a randomized, blinded, controlled clinical trial.
Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 +/- 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25).
Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 +/- 10.6, 44.9 +/- 9.4, 51.2 +/- 11.1, and 59.8 +/- 18.2 nmol/liter, respectively, for the control group; and 33.1 +/- 8.7, 55.0 +/- 11.8, 70.9 +/- 22.0, and 85.7 +/- 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 +/- 0.53 m/sec) to posttest (5.71 +/- 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 +/- 0.73 m/sec) to posttest (5.33 +/- 0.79 m/sec) (P = 0.031).
Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity. (J Clin Endocrinol Metab 95: 4584-4591, 2010)
Details
- Title: Subtitle
- A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D-3 Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness
- Creators
- Yanbin Dong - Augusta UniversityInger S. Stallmann-Jorgensen - Augusta UniversityNorman K. Pollock - Augusta UniversityRyan A. Harris - Augusta UniversityDaniel Keeton - Augusta UniversityYing Huang - Augusta UniversityKe Li - Augusta UniversityReda Bassali - Augusta UniversityDe-Huang Guo - Augusta UniversityJeffrey Thomas - Augusta UniversityGary L. Pierce - Augusta UniversityJennifer White - Augusta UniversityMichael F. Holick - Boston Medical CenterHaidong Zhu - Augusta University
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.95(10), pp.4584-4591
- Publisher
- Endocrine Soc
- DOI
- 10.1210/jc.2010-0606
- PMID
- 20660028
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Number of pages
- 8
- Grant note
- Diabetes and Obesity Discovery Institute at the Medical College of Georgia
- Language
- English
- Date published
- 10/01/2010
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984267245202771
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