Journal article
A 25‐year experience of endomyocardial biopsy safety in infants
Catheterization and cardiovascular interventions, Vol.82(5), pp.797-801
11/01/2013
DOI: 10.1002/ccd.24802
PMID: 23553941
Abstract
Objectives
To analyze the outcomes and risk factors associated with endomyocardial biopsy (EMB) in children less than one year of age.
Background
EMB has proven to be an integral diagnostic tool to evaluate suspected myocarditis, identify tumor histology, and provide tissue‐graft surveillance after cardiac transplantation. The morbidity and mortality of EMB has been well established in the adult literature and reviewed in the general pediatric population, but there remains limited data for children in the first year of life.
Methods
We retrospectively reviewed the cardiology database at our institution to identify patients less than one year of age who underwent EMB between 1984 and 2008. Cardiac catheterization reports were reviewed for patient demographics, biopsy indication, procedural details, and complications.
Results
A total of 99 EMBs were performed, 49 for evaluation of suspected myocarditis, 43 for transplant rejection surveillance, 3 to identify tumor histology, and 4 for suspected endocardial fibroelastosis. Forty procedures were performed in children age < 6 months with 11 complications and 59 procedures performed in children age ≥ 6 months with four complications. In total, there were 12 EMB procedures (12.1%) with associated complications: 9 arrhythmias, 4 perforations requiring pericardiocentesis, 1 pneumothorax, and 1 death. Univariate analysis revealed a significant association between perforation and both weight <8 kg (P = 0.05) and age <6 months (P = 0.01).
Conclusion
Endomyocardial biopsies can be performed safely in infants, although children under 6 months of age and less than 8 kg represent a high risk group and deserve special consideration due to the incidence of complications in this cohort.© 2013 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- A 25‐year experience of endomyocardial biopsy safety in infants
- Creators
- Derek Zhorne - Texas Children's HospitalChristopher J Petit - Texas Children's HospitalFrank F Ing - Texas Children's HospitalHenri Justino - Texas Children's HospitalJohn L Jefferies - Texas Children's HospitalWilliam J Dreyer - Texas Children's HospitalDebra Kearney - Texas Children's HospitalMatthew A Crystal - Texas Children's Hospital
- Resource Type
- Journal article
- Publication Details
- Catheterization and cardiovascular interventions, Vol.82(5), pp.797-801
- DOI
- 10.1002/ccd.24802
- PMID
- 23553941
- ISSN
- 1522-1946
- eISSN
- 1522-726X
- Number of pages
- 5
- Language
- English
- Date published
- 11/01/2013
- Academic Unit
- Stead Family Department of Pediatrics; Hospital Medicine
- Record Identifier
- 9984093601002771
Metrics
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